Thermo Fisher Scientific (Bremen) Gmbh

Ulf Froehlich

Alexander Alekseevich Makarov

Alexander Kholomeev

Oliver Lange

Jan-Peter Hauschild

Eric Wapelhorst

Andreas Wieghaus

An operating value of a first laser parameter of a laser device in a laser absorption spectrometer is optimized. The wavelength of laser device emitted light is adjusted by the first or a second laser parameter. The laser absorption spectrometer comprises a light intensity detector measuring the laser light intensity from the laser device. For each of multiple values of the first laser parameter: the light intensity detector measures light intensity obtained across a range of second laser parameter values, and an extremum in the light intensity measure and a peak position for the extremum are identified. A range of first laser parameter values is identified within the values of the first laser parameter for which there is a continuous trend in changes to the identified peak position with changes to the first laser parameter. The first laser parameter operating value is set to be within the identified range.

Optimization of the laser operating point in a laser absorption spectrometer

A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.

Method and apparatus for mass analysis utilizing ion charge feedback

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Bremen, Germany

Ulf Froehlich