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Uldis Yanovich Mikstais

Solomon Aronovich Giller

Maiya Petrovna Silaya

Guntis Erikovich Berggrin

Paul Alexandrovich Stankevich

Karl Karlovich Venter

Alexandra Semenovna Sopova

Robert Avgustovich Brinkmanis

Vsevolod Vasilievich Perekalin

Maiva Mikhailovna Zobacheva

Rasma Yanovna Spunde

Margarita Aldonovna Trushule

A method of preparing 5-nitrofurfural diacetate which comprises nitration furfural or furfural diacetate at a temperature within the range of from -10.degree. to +10.degree. C; said nitration being effected by the gradual simultaneous addition of furfural or a furfural diacetate solution in acetic anhydride and a mixture of nitric and sulphuric acids into acetic anhydride at a temperature within the range of from -10.degree. to +10.degree. C under continuous stirring of the reaction mixture. In doing so, molar proportions of furfural or furfural diacetate and nitric acid and sulphuric acid are maintained equal to 1:1.1-2:0.036-0.041 respectively and said compounds are added into acetic anhydride at such rates as to maintain the nitration reaction temperature at a predetermined level. The reaction mixture resulting from the nitration is treated with water at a weight ratio between water and the starting acetic anhydride ranging from 1.1:1 to 1.8:1 respectively and at a temperature within the range of from 0.degree. to 15.degree. C; the reaction mixture is then neutralized with an alkali to a pH = 3.5 - 5 at a temperature within the range of from 0.degree. to 25.degree. C, maintained at a temperature of from 45.degree. to 55.degree. C, and the desired product is thereafter isolated from said reaction mixture.

Method of preparing 5-nitrofurfural diacetate

The invention relates to a new substance, namely the hydrochloride of .beta.-phenyl- .gamma.-aminobutyric acid of the following formula: ##EQU1## and to the process for its production which comprises condensing malonic ester with .beta.-nitrostyrene resulting in the separation of an ester of .gamma.-carbomethoxy-.beta.-phenyl-.gamma.-nitrobutyric acid at a temperature ranging from 0.degree. to 14.degree.C, reducing the ester thus obtained with hydrogen in the presence of the Raney nickel under a pressure of 6 to 30 atm, treating 3-carbomethoxy-4-phenyl-2-pyrrolidone, as formed by the reduction, with hydrochloric acid, and separating the desired product.

Process for producing .beta.-phenyl-.gamma.-amino butyric acid

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Uldis Yanovich Mikstais