Galileo Pharmaceuticals, Inc.

Johnson & Johnson Consumer Companies, Inc.

Ughetta Del Balzo

Bing Wang

Lesley A Brown

Wei Zhang

Jiangao Song

Guy M Miller

Sekhar S Boddupalli

Jian Chen

Yong-Kang Zhang

Gail Walkinshaw

Stephen F Flaim

Sylvain Gilat

Steven Bobzin

Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods

The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions.

Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols

Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Furanone derivatives

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Morgan Hill, CA, United States of America

Ughetta Del Balzo