Københavns Universitet

Danmarks Tekniske Universitet

Chr. Hansen Natural Colors A/s

Danmarks Teniske Univesitet

Uffe Hasbro Mortensen

Finn Thyge Okkels

Birger Lindberg Møller

Bjørn Madsen

Rubini Maya Kannangara

Rasmus John Normand Frandsen

Mads Bennedsen

Ulf Thrane

Kim Binderup

Johan Andersen-Ranberg

Majse Nafisi

Paiman Khorsand-Jamal

Kenneth Thermann Kongstad

Dan Stærk

Hilde Cornelijne Coumou

A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C-Caromatic compound of interest (e.g. carminic acid).

Use of octaketide synthases to produce kermesic acid and flavokermesic acid

An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.

Glycosyltransferase glycosylating flavokermesic acid and/or kermesic acid

A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.

Use of heterologous expressed polyketide synthase and small molecule foldases to make aromatic and cyclic compounds

Glycosyltransferase glycosylating flavokermesic acid and/or or kermesic acid

Growing community of inventors

Copenhagen, Denmark

Uffe Hasbro Mortensen