Euro-celtique S.a.

Mundipharma Laboratories Gmbh

Udo Hahn

Walter Wimmer

Stewart Thomas Leslie

Derek Allan Prater

Ronald Brown Miller

Kevin John Smith

Horst Winkler

Sandra Therese Antoinette Malkowska

Sandra Therese Malkowska

Christof Spitzley

Christian Leuner

Bianca Brogmann

Alexander Schuetz

Alexander SCHÜTZ

Stuart Thomas Leslie

A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.

Controlled release tramadol tramadol formulation

The invention is relative to a pharmaceutical preparation, especially for oral administration, with at least one active substance and with formulation components influencing the release of active substance, which preparation comprises at least one opiod analgesic as active substance that is formulated proportionally on the one hand for rapid release and on the other hand for delayed release in such a manner that the in vitro release rate from the preparation according to the Ph. Eur. paddle test shows a mean value of above 40% by weight after one hour and that the in vitro release rate shows a mean value that is still below 80% by weight after four hours.

Opioid analgesic

Controlled release formulation

Controlled release tramadol

Growing community of inventors

Nentershausen, Germany

Udo Hahn