Lancaster Group Ag

Bausch-lomb Incorporated

Humboldt-universitaet Zu Berlin

Nanofluor Gmbh

Udo Gross

Leonhard Zastrow

Klaus Stanzl

Joachim Roding

Erhard Kemnitz

Dirk-Henning Menz

Karin Kobuch

Hans Hoerauf

Stephan Ruediger

Stephan RÜDIGER

The present invention is related to a method for preparing an amorphous metal fluoride of the formula MFcomprising the steps of

Method for the preparation of high surface area metal fluorides

The invention relates to the utilization of a highly fluorinated oligomeric alkane as a therapeutic agent in ophthalmology, the alkane having the general formula [&#x2014;R(CH)CR&#x2014;CR&#x2014;], wherein Ris a linear or branched perfluorinated alkyl chain CFto CF, Rand Rare independently selected from the group consisting of H, CH, CHand CH, n is selected from the numbers 0, 1 and 2, and x is a number between 2 and 6, with a molar mass of at least 750. According to the invention, a pharmacological agent is provided that is used in ophthalmology and that causes little or no damage to the retina even when used over a long period.

Utilization of a highly fluorinated oligomeric alkane in ophthalmology

The invention relates to pharmaceutical compositions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical administration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100% weight/volume, in a pharmaceutical excipient which is suitable for topical administration. Preparation is effected by emulsification of the appropriate constituents and use in ointments, creams, lotions, pastes, gels, powders or on a dressing or plaster or by means of a spray.

Pharmacological composition for topical administration

The invention relates to a cosmetic for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known cosmetics is the inadequate oxygen supply to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by a cosmetic containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier suitable for dermatological use. Preparation is effected by emulsification of the corresponding constituents, and use in ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or on dressings and plasters or in a spray.

Phospholipid-and fluorocarbon-containing cosmetic

The invention relates to a preparation for topical use, having light protection properties and in a special application form. In the known light protection agents containing the naturally occurring active compound melanin, the problem is inadequate transport of the melanin to its site of action. According to the invention, this problem is solved by a preparation for topical use which is characterised in that it contains melanin, dissolved or dispersed in one or more fluorocarbons, which are present as asymmetric lamellar phospholipid aggregates in an aqueous system together with a phospholipid, with a particle size of the aggregates in the range from 200 to 3000 nm.

Preparation for topical use

Dermatological agent for assisting the transport of oxygen in the skin

Growing community of inventors

Berlin, Germany

Udo Gross