Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Bayer Pharma Aktiengesellschaft

Bayer Aktiengesellschaft

Hoeschst Aktiengesellschaft

Sanofi-a Ventis Deutschland Gmbh

Peter Crause

Hans-hochen Lang

Heinz-werner Kleemann

Jan-robert Schwark

Udo Albus

Andreas Weichert

Wolfgang Scholz

Andreas Gerhard Weichert

Heinz-Werner Kleemann

Jan-Robert Schwark

Hans-Jochen Lang

Joachim Brendel

Hans Jochen Lang

Heinrich Christian Englert

Klemens Lustig

Michael Hahn

Martina Delbeck

Doris Gehring

Björn Rosenstein

Thomas Ernst Müller

Hans-Willi Jansen

Karl Collins

Janine Nicolai

Moritz Beck-Broichsitter

Dieter Mania

Heinrich Meier

Niels Lindner

Luisella Toschi

Heinz-Werner Kleeman

Florian Lang

Johanna Mosig

Bansi Lal

Wolfgang Linz

Johanna Anlahr

Anil Vasantrao Ghate

Thomas Müller

Hongkai Dang

Dehe Duan

Jianfei Yang

Denghui Chen

Thomas Muller

Bjorn Rosenstein

Hans-Hochen Lang

Andreas G Weichert Dr

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, such as compounds of the general formula (I): to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders

The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle. 

Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders

The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.

Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same

Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them

Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them

Heterocyclically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them

Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic , and medicament containing them

Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them

Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them

Pharmaceutical combination preparation of an inhibitor of the sodium/hydrogen exchanger and a medicament for the treatment of cardiovascular diseases

Methods of using 2-amino-3,4-dihydroquinazolines of formula I, or a pharmaceutically tolerable salt thereof, for the treatment or prophylaxis of illnesses caused by ischemic conditions:

Use of 2-amino-3,4-dihydroquinazolines for the production of a medicament for the treatment or prophylaxis of illnesses caused by ischemic conditions

Methods of using 2-imidazolyl-substituted carbinols of the formula I for treating or preventing diseases caused by ischemic conditions:

Use of 2-imidazolyl-substituted carbinols for the production of a medicament for the treatment or phophylaxis of diseases caused by ischemic conditions

Ortho-substituted benzoylguanidines of the formula I

Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

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Florstadt, Germany

Udo Albus