Merial Limited

Celgene Car LLC

Theratech, Inc.

Boehringer Ingelheim Vetmedica Gmbh

Uday Jain

Alexander L Ruchelman

Jean Xu

Lianfeng Huang

Susan Mancini Cady

Ying Li

Robert Chapman

Daozhong Zou

Chunhua Yang

John Malona

Chittari Pabba

Jianxin Han

Kevin Molter

Baoqing Ma

Charles D Ebert

Srinivasan Venkateshwaran

Robert Clark Chapman

The present invention provides solid forms of an MK2 inhibitor, compositions thereof, and methods of using the same.

Forms and compositions of a MK2 inhibitor

This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.

Long-acting injectable moxidectin formulations and novel moxidectin crystal forms

A stabilized patch device for transdermal drug delivery of steroid drugs containing a 3-keto-4-en functional group is described, wherein the patch comprises an effective amount of the steroid drug and a carrier that is free of acid functional groups. The device can further contain additives such as a penetration enhancer or excipient, so long as such additives are also free of acid functional groups. The device can be either a matrix patch or a liquid reservoir patch. In a matrix patch, the carrier is a biocompatible polymeric adhesive with which the steroid drug is intimately admixed. The adhesive is preferably an acrylic polymer or copolymer. In a liquid reservoir patch, the carrier is a controlled-viscosity composition containing a thinner or thickener. Preferred steroid drugs include certain corticosteroids and sex hormones, such as progestins and androgens. A method of stabilizing such steroid drugs during storage in transdermal patches is also disclosed.

Drug delivery compositions for improved stability of steroids

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Plainsboro, NJ, United States of America

Uday Jain