The Institute of Cancer Research: Royal Cancer Hospital

The Royal Marsden Nhs Foundation Trust

Udai Banerji

The present invention provides a method for the treatment or prevention of a cell proliferative disorder, the method comprising: or a pharmaceutically acceptable salt thereof twice weekly for 3 weeks,

Coumarin derivative for therapy or prophylaxis of a cell proliferative disorder

This invention relates to methods comprising administering a FAK inhibitor (e.g., VS-6063) in combination with a dual RAF/MEK inhibitor (e.g., CHS 126766) that are useful in the treatment of abnormal cell growth, such as cancer, in a subject such as humans.

Therapeutic compositions, combinations, and methods of use

The present invention provides a medicament for the treatment or prevention of a cell proliferative disorder, the medicament comprising as an active ingredient a compound represented by formula or a pharmaceutically acceptable salt thereof, wherein the medicament is used in such a manner that: (a) said compound or salt is administered twice weekly for 3 weeks, (b) administration of said compound or salt is paused for the following 1 week, and (c) steps (a) and (b) are subsequently repeated at least once. 

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Udai Banerji