Closure Medical Corporation

Ubonwan A Stewart

Timothy P Hickey

Jerry Y Jonn

Upvan Narang

John S Bobo

Ibraheem T Badejo

Daniel L Hedgpeth

William S C Nicholson

Andres Rivera

Lawrence H Mainwaring

Melanie Vander Klok

Adhesive compositions, particularly medical adhesive compositions, often include several components that may react differently to different sterilization processes, particularly when combined with one another. The present invention is directed to methods of sterilizing different components or groups of components of a final adhesive composition. The different components or groups of components may be sterilized in separate containers before packaging the components or groups of components within a kit, and thereafter sterilizing the kit.

Sterilization of medical adhesive kits

A method of making a sterile adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a thickening agent in a container, sealing the container, and sterilizing the mixture and the container. The method provides superior viscosity for the monomer composition. An adhesive composition includes 2-octyl cyanoacrylate and at least one thickener. The sterile adhesive composition is particularly useful as a medical adhesive and can comprise 1,1-disubstituted ethylene monomers, such as &agr;-cyanoacrylates.

Sterilized cyanoacrylate solutions containing thickeners

An adhesive composition that contains a preservative is particularly useful as a medical adhesive and can include alkyl cyanoacrylate monomers. The preservative is preferably soluble in the monomer. The composition may optionally be sterilized by placing a mixture of a polymerizable adhesive monomer and a preservative in a container, sealing the container, and sterilizing the mixture and the container.

Cyanoacrylate solutions containing preservatives

A method of making a sterile adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a thickening agent in a container, sealing the container, and sterilizing the mixture and the container. The method provides superior viscosity for the monomer composition. The sterile adhesive composition is particularly useful as a medical adhesive and can comprise 1,1-disubstituted ethylene monomers, such as &agr;-cyanoacrylates.

A method for sterilizing a liquid adhesive composition includes subjecting the composition to electron beam irradiation while it is enclosed in a container.

Electron beam sterilization of liquid adhesive compositions

Treatment methods for glass medical adhesive applicators in which a glass applicator is exposed to ammonium sulfate, an acidic gas, a plasma or a silanizing agent in order to remove or coat alkalide materials trapped in the glass.

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Durham, NC, United States of America

Ubonwan A Stewart