China Medical University

Everfront Biotech Inc.

National Dong Hwa University

Gwo Xi Stem Cell Applied Technology Co., Ltd.

Buddhist Tzu Chi Medical Foundation

Hawking Biological Technology Co., Ltd.

Tzyy-Wen Chiou

Horng-Jyh Harn

Shinn-Zong Lin

Po-Cheng Lin

Hong-Lin Su

Mao-Hsuan Huang

Kuo-Wei Hsueh

Ssu-Yin Yen

Cheng-Han Wu

Sheng-Feng Tsai

Shih-Ping Liu

Jeanne Hsieh

Kang-Yun Lu

Chia-Yu Chang

Haile Fentahun Darge

Chang-Yi Lee

Hsieh-Chih Tsai

Yu-Shuan Chen

Hui-I Yang

Hsiao-Chien Ting

Tsung-Jung Ho

Ching-Ann Liu

Karthyayani Rajamani

Li-Fu Chang

Hen-Yi Chu

Yu-Han Chiu

Yi-Wen Chou

Shinn-Zong Ling

Yi-Chun Lin

Hong-Meng Chuang

Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.

Transdermal delivery device, methods of using and making the same

Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.

Method for prevention or treatment of amyotrophic lateral sclerosis by administering gastrodin

Applications of butylidenephthalide (BP), comprising the use of BP in providing a kit for promoting differentiation of stem cells into brown adipose cells, and the use of BP in preparing a medicament, wherein the medicament is used for inhibiting the accumulation of white adipose cells, promoting the conversion of white adipose cells into brown adipose cells, inhibiting weight gain and/or reducing the content of triglycerides, glucose, and total cholesterol in blood.

Applications of butylidenephthalide

A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.

Method for the anti-senescence of and/or rejuvenating stem cells

A method for providing an increased expression of at least one of telomerase, brain-derived neurotrophic factor (BDNF), stromal cell-derived factor-1 (SDF1), CXC chemokine receptor 4 (CXCR4), and an immune regulatory factor of a stem cell in a subject is provided. The method comprises simultaneously or separately administering to the subject an effective amount of (a) a phthalide and (b) a stem cell.

Method for providing an increased expression of telomerase, brain-derived neurotrophic factor, stromal cell-derived factor-1, CXC chemokine receptor 4, and/or immune regulatory factor of stem cell

A method for decreasing the incidence rate and/or recurrent rate of cancer is provided. The method comprises administering to a subject in need an effective amount of butylidenephthalide (BP).

Uses of butylidenephthalide

A method for at least one of activating autoimmune system and treating cancer is provided. The method comprises administering to a subject in need an effective amount of Z-butylidenephthalide and an effective amount of mononuclear cells.

Use of Z-butylidenephthalide in activating autoimmune system

A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.

Mesenchymal stem cell extract and its use

The present invention relates to a method of delaying the onset of pulmonary fibrosis or treating pulmonary fibrosis, comprising administering to a subject in need an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein,

Method for delaying the onset of pulmonary fibrosis or treating pulmonary fibrosis

A method for treating and/or delaying the degeneration of Purkinje cells in a subject is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a medicament, wherein the medicament comprises a phthalide selected from the group consisting of n-butylidenephthalide (BP), a metabolic precursor of BP, a pharmaceutically acceptable salt of a metabolic precursor of BP, a pharmaceutically acceptable ester of a metabolic precursor of BP, and combinations thereof.

Method for treating and/or delaying the degeneration of Purkinje cells

A method for treating pancreatic cancer is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical formulation, wherein the pharmaceutical formulation comprises (Z)-butylidenephthalide and is substantially free of (E)-butylidenephthalide.

Method for treating pancreatic cancer

This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.

Anticancer formulation

Stable pharmaceutical composition

A method for improving skin appearance and/or reducing hair loss in a subject is provided. The method comprises administrating to the subject an effective amount of peripheral monocytes, wherein the peripheral monocytes are induced by granulocyte colony stimulating factor (GCSF) or a combination of GCSF and an interleukin relative to GCSF.

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Hualien, Taiwan

Tzyy-Wen Chiou