Senesco, Inc.

Senesco Technologies, Inc.

Tzann-Wei Wang

John E Thompson

Dongen Lily Lu

Catherine Taylor

John C Carlson

Larry Petrov

Richard Narayansingh

Dominic O Cliche

Katalin A Hudak

Marianne Kaup

Yuwen Hong

Marianne Hopkins

Linda Nowack

Wendy Wu

Dominic 75 Old Chicopee Drive Cliche

The present invention relates to unique isoforms of eukaryotic initiation Factor 5A ('eIF-5A'): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase ('DHS'), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.

Isoforms of eIF-5A: senescence-induced eIF5A; wounding-induced eIF-5A; growth eIF-5A; and DHS

The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Method for inducing apoptosis using apoptosis-specific EIF5-A

Expression vector encoding apoptosis-specific eIF-5A

The present invention relates to unique isoforms of eukaryotic initiation Factor 5A ('eIF-5A'): senescence-induced eIF-5A; wounding/pathogen induced eIF-5A; stress eIF-5A and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase ('DHS'), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.

Method of increasing seed yield and growth eIF-5A

Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced elF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced elF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants.

DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants

Isoforms of eIF-5A: senescence-induced eLF5A; wounding-induced eIF-4A; growth eIF-5A; and DHS

Polynucleotides encoding carnation senescence-induced DHS

Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced eIF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced eIF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants.

Isolated nucleotides encoding arabidopsis senescence-induced elF-5A

Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis

Regulation of expression of senescence in plants is achieved by integration of a gene or gene fragment encoding senescence-induced lipase into the plant genome in antisense orientation. The carnation andgenes encoding senescence-induced lipase are identified and the nucleotide sequences are used to modify senescence in transgenic plants.

DNA encoding a plant lipase, transgenic plants and a method for controlling senescence in plants

Isolated nucleotides encoding tomato senescence-induced eIF-5A

Polynucleotides encoding carnation senescense-induced EIF-5A

DNA encoding a plant deoxyhpusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants

Tomato antisense deoxyhypusine synthase molecule and method of inhibiting deoxyhypusine synthase expression in plants

Growing community of inventors

Waterloo, Canada

Tzann-Wei Wang