University of Virginia Patent Foundation

Hampton University

Tyvin A Rich

Mahendra Devichand Chordia

Dongfeng Pan

Alexander V Kirichenko

The present application provides compositions and methods for preparing and using 'heavy' nucleotide derivatives of thymidine or uridine by replacing the oxygen atom attached to one or more of positions with non-radioactive oxygen-18 (O), administering it to a subject to target a tumor including incorporation into tumor cell DNA, and then treating the tumor with proton beam therapy to transmutate theO toF, resulting in a break of the new fluorine-phosphorous bond. This chemical event destabilizes ribose-phosphate DNA back-bone and base pairing thus produce single- and double strand breaks, clusters lesions that can lead to irreparable DNA damage and enhanced tumor cell killing. The atomic, chemical, and physical aspects result in the use of lower radiation doses and significantly alter acute and late morbidity of radiotherapy. Heavy thymidine and heavy uridine derivatives labeled withO have been made and tested.

Proton activated atomic medicine

A method is provided for assessing the functional integrity of a mucosal membrane, comprising: (a) locally administering a dosage of a radionuclide to the surface of a mucosal membrane of a mammal; and (b) employing dynamic scintigraphy to measure the absorption of the radionuclide into the bloodstream of the mammal.

Growing community of inventors

Charlottesville, VA, United States of America

Tyvin A Rich