Massachusetts Institute of Technology

The Scripps Research Institute

Tyson Moyer

Darrell J Irvine

Karl Dane Wittrup

Yash Agarwal

William Ray Schief

Mark Bathe

Remi Veneziano

Eike-Christian Wamhoff

Benjamin Joseph Read

The present disclosure provides immunomodulatory fusion proteins-metal hydroxide complexes comprising an immunomodulatory domain adsorbed to a metal hydroxide via ligand exchange. The disclosure also features compositions and methods of using the same, for example, to treat cancer.

Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof

Compositions containing a nucleic acid nanostructure having a desired geometric shape and antigens bound to its surface are provided. The nanostructures can be, for example, in the form of a 6-helix bundle or icosahedron. The nanostructure design allows for control of the relative position and/or stoichiometry of the antigen bound to its surface. The antigens displayed on the nanostructure surface are arranged with the preferred number, spacing, and 3D organization to elicit a robust immune response. The displayed antigen can be an HIV immunogen such as eOD-GT6, eOD-GT8, or variants thereof. The compositions may thus be useful as immunogens, vaccines, immunostimulators, adjuvants, and the like. Methods of inducing immune responses, inducing protective immunity, inducing the production of neutralizing antibodies or inhibitory antibodies, inducing tolerance, and treating cancer, infectious or autoimmune diseases are also provided.

Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom

The present disclosure relates to compositions and methods for coupling an antigen to an adjuvant, immunogenic compositions and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.

Antigen-adjuvant coupling reagents and methods of use

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Boston, MA, United States of America

Tyson Moyer