Bio-rad Innovations

Typhaine Dagland

Francois Yves Rieunier

The present invention relates to a double-stranded probe intended for the fluorescent detection of at least one single-stranded or double-stranded target nucleic acid, comprising: &#x2014;a first strand of formula X1-(L1)a-S1-S'1-(L&#x2032;1)b-Y1 intended for the detection of a first strand of the target nucleic acid which comprises a sequence of formula T&#x2032;1-T1; &#x2014;a second strand of formula X2-(L2)c-S2-S&#x2032;2-(L&#x2032;2)d-Y2 intended for the detection of a second strand of the target nucleic acid, if present, the second strand of the target nucleic acid comprising a sequence of formula T&#x2032;2-T2; wherein two of X1, X2, Y1, and Y2 represent a fluorescent donor, while the two others represent a fluorescent acceptor, and X1 and Y2 can not both represent a fluorescent donor.

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Vaucresson, France

Typhaine Dagland