University of California

Invizyne Technologies, Inc.

Tyler P Korman

James U Bowie

Paul H Opgenorth

Nicholas Woodall

Meaghan Valliere

Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions.

Biosynthetic platform for the production of cannabinoids and other prenylated compounds

The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.

Prenyltransferase variants with increased thermostability

Provided is an engineered pathway that can function in a cell-free system, cellular system or a combination thereof to convert a sugar to a chemical or biofuel.

Cell-free metabolic pathway for glucose metabolism with a molecular purge valve

The disclosure provides a metabolic pathway for producing a metabolite, the metabolic pathway having a co-factor purge valve system for recycling a cofactor used in the metabolic pathway.

Synthetic biochemistry molecular purge valve module that maintain co-factor balance

The disclosure provides a metabolic pathway for producing a metabolite, the metabolic pathway having a co-factor regulatory system for cofactor utilization in the metabolic pathway.

Growing community of inventors

Sierra Madre, CA, United States of America

Tyler P Korman