Astrazeneca Ab

Tyler Grebe

Jason Grant Kettle

Maurice Raymond Verschoyle Finlay

Iain Simpson

Sameer Pralhad Kawatkar

Dedong Wu

Frederick Woolf Goldberg

Neil Patrick Grimster

Scott Nathan Mlynarski

Steve Cook

Jianyan Wang

Li Sha

Adelphe Mfuh

Ye Wu

Amber Balazs

Robert Evans Ziegler

Anthony Metrano

Kun Song

Randolph Escobar

Lucas Morrill

Sten Nilsson Lill

Kathryn Giblin

Disclosed are compounds of formula (Ib) or (Vc), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ib) or (Vc) and methods of using the same for treating cancer, respiratory inflammatory disease, and inhibiting arginase; wherein Ris —H or —C(O)CH(R)NHR; and Ris selected from —H, —(C-C) alkyl and CHOR; Ris —H; or alternatively, Rand R, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and Ris H or —CH.

Arginase inhibitors and methods of use thereof

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

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Tyler Grebe