Advanced Cardiovascular Systems, Inc.

Ty T Hu

Syed F A Hossainy

Fuh-Wei Tang

Dorie M Happ

Kurt W Scheinpflug

Jeff Royal

Dorrie M Happ

Stephen D Pacetti

Paul M Consigny

Gordon S Stewart

Mark A Williams

Shamim M Malik

Jean-Francois Corbett

A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.

Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin

A stent mandrel fixture for supporting a stent during the application of a coating substance is provided.

Stent mandrel fixture and method for reducing coating defects

A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

40-O-(2-hydroxy)ethyl-rapamycin coated stent

A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating.

Thermal treatment of a drug eluting implantable medical device

A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition which can result in reduction of the rate of release of an active agent from the coating subsequent to the implantation of the device.

A method and apparatus for inhibiting vascular restenosis using a radioactive implantable medical device and a radiosensitizer agent. In one embodiment, the method of the invention includes implanting a medical device at a blood vessel site that has undergone a procedure to open a stenosed region within a blood vessel. The medical device contains a radioisotope to emit a radioactivity to a tissue mass at the blood vessel site. The method further includes delivering a radiosensitizer agent to the tissue mass at the blood vessel site. The radiosensitizer agent increases a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope.

Radiation therapy using a radioactive implantable device and a radiosensitizer agent

A method for delivering multiple doses of radiation to a target area of a vessel. The method includes delivering multiple radioisotopes to a target area of a vessel and allowing the radioisotopes to dwell in the target area for a period of time to deliver a predetermined and uniform radiation dose.

Method for radioactive stent delivery

An apparatus and methods for modifying a surface of a target. The apparatus includes a reaction vessel having a reaction chamber. A cylindrical or spherical grid is positioned within the chamber. An electrode is also positioned within the chamber. A target can be positioned within the chamber and within the grid. A voltage source is operatively associated with the target and with the grid to separately but concurrently provide an independently variable voltage to both the grid and the electrode.

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Pembroke Pines, FL, United States of America

Ty T Hu