Genentech, Inc.

Twyla Noelle Lombana

Christoph Spiess

Teemu T Junttila

Diego Ellerman

Dionysos Slaga

Michael Patrick Dillon

Marissa L Matsumoto

Jack Bevers, Iii

Karthik Veeravalli

Jeong Kim

Jill M Schartner

Rebekah McKenna

Evangeline Toy

Zhengmao Ye

Ryan Cook

Amy Berkley

The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.

Bispecific antigen-binding molecules and methods of use

The invention provides anti-MIC antibodies and methods of using the same.

Anti-MIC antibodies and methods of use

The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.

Methods of identifying bacteria comprising binding polypeptides

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San Francisco, CA, United States of America

Twyla Noelle Lombana