Elan Pharma International Limited

Alkermes Pharma Ireland Limited

Fournier Laboratories Ireland Limited

Recro Pharma, Inc.

Baudax Bio, Inc.

Bgp Products Ireland Limited

Tuula Ryde

John Dallas Pruitt

Eugene Rex Cooper

Douglas C Hovey

Evan E Gustow

Stephen B Ruddy

Rajeev A Jain

Rakesh A Patel

Laura Kline

Michael John Wilkins

H William Bosch

Niels Peter Ryde

Robert G Reed

David A Czekai

Greta G Cary

Elaine Merisko-Liversidge

Rajeev Jain

Rajeev c/o Elan Drug Delivery Jain

Amy Walters

The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm.

Nanoparticulate meloxicam formulations

The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.

Nanoparticulate megestrol formulations

The present invention is directed to nanoparticulate compositions comprising meloxicam. The meloxicam particles of the composition have an effective average particle size of less than about 2000 nm.

The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.

Nanoparticulate fibrate formulations

The present invention is directed to nanoparticulate compositions comprising topiramate. The topiramate particles of the composition have an effective average particle size of less than about 2 microns.

Nanoparticulate topiramate formulations

Methods of treatment using nanoparticulate fenofibrate compositions

A small-scale or micro media-mill and a method of milling materials or products, especially pharmaceutical products, use a dispersion containing attrition milling media and the product to be milled. The milling media can be polymeric, formed of polystyrene or cross-linked polystyrene, having a nominal diameter of no greater than 500 microns. Other sizes include 200 microns and 50 microns and a mixture of these sizes. The mill has a relatively small vessel having an opening, an agitator, a coupling, and a motor. The agitator can have a rotor and a shaft extending therefrom. The rotor can be cylindrical or have other configurations, and can have tapered end surfaces. The coupling can close the vessel opening, or attaching the coupling to the motor can close the opening. The coupling has an opening through which the rotor shaft extends into the motor. A sealing mechanism, such as a mechanical or lip seals the shaft while permitting the rotor shaft to rotate. The vessel can contain one or more ports for circulating the dispersion, where milling can be made in batches or recirculated through the milling chamber. The media can be retained in the vessel or recirculated along with the process fluid. The rotor is dimensioned so that its outer periphery is spaced with a small gap from an inner surface of the vessel. The vessel also can have a way of cooling the dispersion.

Small-scale mill and method thereof

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Malvern, PA, United States of America

Tuula Ryde