Orion Corporation

Tuula Koskelainen

Arto J Karjalainen

Sirpa Rasku

Leena Otsomaa

Mikko Kalervo Mäkelä

Olli Törmäkangas

Pentti T Nore

Jouko Levijoki

Eija Tiainen

Piero Pollesello

Tero Linnanen

Jukka Tenhunen

Antti Pohjakallio

Anna Minkkilä

Pekka Kotovuori

Mikko Mäkelä

Anna MinkkilÄ

Compounds of formula (I), wherein X and R-R, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.

Alpha2 adrenoceptor agonists

Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na/Caexchange mechanism.

Pyridine derivatives useful for inhibiting sodium/calcium exchange system

Therapeutically active compounds of formula (I): wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of the Na/Caexchange mechanism.

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Lohja as, Finland

Tuula Koskelainen