Fuisz Technologies Ltd.

Biovail Technologies Ltd.

Tushar K Misra

Pradeepkumar P Sanghvi

Michael G Raiden

John R Sisak

Satish V Kamath

Jeffery W Currington

Richard C Fuisz

Subraman R Cherukuri

Steven E Frisbee

Mahendra Govind Pankhania

Barbara Montwill

John J Getz

David V Prior

Jeffrey W Currington

Pradeep P Sanghvi

The invention deals with the use of low temperature and low humidity conditions during the storage and shaping of &ldquo;flash-dose&rdquo; tablet compositions. The compositions may be rendered substantially non-amorphous before tablet formation.

Easily processed tablet compositions

Bioaffecting sachets, or powders, containing coated liquiflash microspheres and partially recrystallized shearform floss particles are disclosed. The sachets give organoleptically acceptable properties, including a pleasing mouthfeel, when orally ingested.

Sachet formulations

The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly in the mouth with optional chewing. The compositions typically include shearform matrices which have been recrystallized using crystallization promoters.

Fast-dissolving comestible units formed under high-speed/high-pressure

A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.

Self-binding shearform compositions

The present invention deals with compositions and methods for preparing comestible units which disperse quickly in the mouth, especially when chewed. The present invention also includes the product made therefrom. The method includes initiating crystallization of shearform matrix with crystallization/bindig promoter and combining it with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.

Process for forming chewable quickly dispersing comestible unit and

The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly when placed in the mouth. The compositions typically include partially hygroscopic shearform matrices which may be recrystallized using crystallization promoters.

Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.

Controlled release dosage forms containing water soluble drugs

Shearform compositions made without added glycerine are disclosed. The compositions are self-binding and exhibit excellent cohesivity when used in tableting compositions. Typically, xylitol is incorporated into a feedstock which is flash-flow processed to form a self-binding shearform matrix.

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Leesburg, VA, United States of America

Tushar K Misra