3m Innovative Properties Company

Coley Pharmaceutical Group, Inc.

Tushar A Kshirsagar

Philip D Heppner

Bryon A Merrill

Shri Niwas

Michael E Danielson

Joshua R Wurst

George W Griesgraber

Michael J Rice

Scott E Langer

Kyle J Lindstrom

Gregory D Lundquist, Jr

Chad A Haraldson

Sarah J Slania

David T Amos

Thomas Edward Wood

John F Gerster

David S Hays

Manjiri T Kshirsagar

Joseph F Dellaria, Jr

William H Moser

Maureen Ann Kavanagh

Sarah A Strong

Matthew R Radmer

Ryan B Prince

Joan T Moseman

Bernhard M Zimmermann

Karl J Manske

Jason D Bonk

Azim Alan Celebi

G Marco Bommarito

Gregory J Marszalek

Doris Stoermer

Larry R Krepski

Robert A Asmus

Bernard A Gonzalez

Patrick A Mach

Scott A Burton

Louis C Haddad

William E Foltz

Paul J Cobian

Gustavo H Castro

Joseph J Stoffel

Francois Ahimou

Tera M Nordby

Hugues M H Martin

Sarah C Johannessen

Sarah C Slania

Sarah Johannessen

David J Squire

Hugues Martin

A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.

Microorganism concentration process

The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety, wherein the covalent link comprises a labile bond directly attached to the IRM moiety.

Immune response modifier compositions and methods

Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Alkoxy substituted imidazoquinolines

Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines

A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a particulate concentration agent that comprises gamma-FeO(OH); (b) providing a fluid sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the concentration agent is dispersed in the sample and at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.

Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Pyrazolopyridines and analogs thereof

Sterilization indicators that include a neutralizer, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.

Self-contained sterilization indicators including a neutralizer for residual oxidizing sterilant

A concentration agent for capture of microorganisms, including diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof, and methods for making the concentration agent.

Microorganism concentration agent and method of making

A method of preferentially inducing IFN-&#x3b1; biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-&#x3b1; biosynthesis in an animal are disclosed.

Method of preferentially inducing the biosynthesis of interferon

A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.

Sample acquisition device

Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Oxime substituted imidazo-containing compounds

Growing community of inventors

Woodbury, MN, United States of America

Tushar A Kshirsagar