Other

Schering Aktiengesellschaft

Hzi Research Center Inc.

Turan M Itil

Emin Eralp

Werner Martin Herrmann

Nils E Johansson

Gerhard Laudahn

Pierre LeBars

Donald M Shapiro

A method and system for acquisition, transmission, analysis, and analysis reporting of patient bioelectrical data, including electroencephalogram (EEG), computer-enhanced and expanded EEG (CEEG), dynamic brain mapping, evoked potentials (EP) and event related potential (ERP) data, with or without dynamic brain mapping, between a remote site where the physician and patient are located and a data collection and analysis center where the data can be analyzed by high-level computer analysis and/or expert technicians using an available communications channel. The EP, ERP and/or EEG data signals are gathered locally and transmitted using a local computer unit to control stimulus generation, data acquisition, and transmission functions. The high-level or computationally-intensive computer at the data collection and analysis center can also generate brain mapping analysis. The analysis results, along with statistical comparisons of the patient condition at the remote site with the data bases (normals, diagnostic groups, psychotropic drug data bases) at the receiving center are transmitted back over a communications channel to the remote site for display to the physician and patient.

Transmitting, analyzing and reporting EEG data

An electrode assembly for an EEG headset has a cylinder and piston, at least one disk-shaped mounting element with an inner portion for mounting the cylinder therethrough and an outer portion overlapping onto the liner of the headset, an electrode body made of insulative material mounted to the piston and holding an electrode tip, and an electrode tip made of conductive material with a wire lead for transmitting electrical signals from the tip to an external signal processing unit separately from the rest of the electrode assembly. Preferably, the mounting element is a pair of rubber washers supporting the cylinder from each side of the liner. The electrode body has a threaded end for threading in the piston, and a central passage for supplying electrolyte gel to the electrode tip. The electrode tip has a disk shape with a relatively large surface area for maintaining good contact with the subject's scalp. The electrode body may also have a ball joint between its piston-mounting portion and tip-holding portion. Other types of electrode tips may be mounted on the assemblies. The headset and electrode structures provide a shorter signal transmission system, which greatly reduces extraneous noise, and allow for direct connection to an external recording or EEG device. The headset may include signal conditioning hardware in the form of a VLSI digital amplifier/signal conditioning unit that can output analog, digital, or telephonic modulated EEG signals, or an FM telemetry system mounted on the headset for wireless transmission.

Electrode assembly for EEG headset

An electrode assembly for an EEG headset has a cylinder and piston, at least one disk-shaped mounting element with an inner portion for mounting the cylinder therethrough and an outer portion overlapping onto the liner of the headset, an electrode body made of insulative material mounted to the piston and holding an electrode tip, and an electrode tip made of conductive material with a wire lead for transmitting electrical signals from the tip to an external signal processing unit separately from the rest of the electrode assembly. Preferably, the mounting element is a pair of rubber washers supporting the cylinder from each side of the liner. The electrode body has a threaded end for threading in the piston, and a central passage for supplying electrolyte gel to the electrode tip. The electrode tip has a disk shape with a relatively large surface area for maintaining good contact with the subject's scalp. The electrode body may also have a ball joint between its pistonmounting portion and tip-holding portion other types of electrode tips may be mounted on the assemblies. The headset and electrode structures provide a shorter signal transmission system, which greatly reduces extraneous noise, and allow for direct connection to an external recording or EEG device. The headset may include signal conditioning hardware in the form of a VLSI digital amplifier/signal conditioning unit that can output analog, digital, or telephonic modulated EEG signals, or an FM telemetry system mounted on the headset for wireless transmission.

An electrode assembly is mounted in a helmet like headset for use in making multiple electrode contact with the scalp. Each electrode assembly includes an electrode that floats in a cylinder mounted in a pressure responsive drive, which, when under pressure carries the electrode toward the scalp of a patient wearing the headset. Mounted in the cylinder above the electrode and biased away from the electrode is an LSI chip carrying an operation amplifier and a power supply for the amplifier. When the electrode makes contact with the scalp the cylinder continues to drive forward. Back pressure from contact with the scalp overcomes the bias and completes a circuit to turn on the amplifier. The amplifier is connected via wire or a wireless signal transmit system to a computer into which amplified signals are fed.

Enhanced electrode headset

Method and apparatus are provided for use in conducting an electroencephalographic (EEG) test where the apparatus includes a headset suitable for placement on the head of a subject to be tested. A plurality of electrodes are mounted on the headset at pre-determined positions about the headset. The electrodes are preferably mounted to the headset by the use of a resilient material, preferably a resilient wire or plastic mesh which is bonded to both the electrode assembly and to the headset. Each of the electrode assemblies include a separate air cylinder for displacing the electrode in the direction of the subject's head upon the application of additional air pressure into the cylinder. A bellows arrangement is provided within each air cylinder for effecting displacement of the electrode. Means are further provided for dispensing a predetermined amount of an electrolytic material from an external source of electrolyte, through the electrode, to the point of contact between the electrode and the subject's head.

Method and apparatus for conducting brain function diagnostic test

Estradiol valerate has been discovered to possess neuropsychotropic activity, e.g., it is an effective anti-depressant having advantageous properties.

Use of estradiol valerate as an anti-depressant

A method of treating patients having a psychiatric condition such as schizophrenia, or having an anxiety syndrome or other neurosis, comprising administering to such patient a therapeutically effective amount of a compound having the formula ##STR1##

Tetracyclic psychotropic drug

Lisuride can be administered to persons prior or subsequent to the ingestion of alcohol to block the behavioral and physiological effects of the alcohol.

Lisuride in alcoholism

Norgestrel, its D- and L-enantiomers and their 17-esters exhibit neuropsychotropic activity when administered in effective dosages to patients exhibiting neuropsychic disturbances of the affective and behavioral type.

Neuropsychotropic agents and their use

Lisuride and its acid addition salts are effective to achieve psychic energizer effects in patients having psychic disturbances who respond poorly to the effects thereof at lower dosages at higher dosages of from 300 to 1,000 .mu.g.

Lisuride and physiologically acceptable salts thereof to achieve psychic

Lisuride and its acid addition salts are used to achieve psychic energizer effects.

Growing community of inventors

Nyack, NY, United States of America

Turan M Itil