Sinew Pharma Inc.

National Defense Education and Research Foundation

Tung-Yuan Shih

Oliver Yoa-Pu Hu

Cheng-Huei Hsiong

Hsin-Tien Ho

Oliver Yao-Pu Hu

Compounds are of the structure of Formula (II) wherein: each X is —C(═O)—; Ris a C-Calkyl polyol; Ris a saccharide group of formula (G); G is a monosaccharide residue, where (i) at least one of the —OH groups in (G)is substituted by a halogen atom, and (ii) the saccharide group of formula (G)is linked to —O— through a —CHgroup; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. The compounds are effective in treating hepatotoxicity and fatty liver diseases.

Substituted esters containing polyols and saccharides for treating hepatotoxicity and fatty liver diseases

A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver. The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, acrylic resin S100, carboxymethyl cellulose sodium, polyoxyethylene polyoxypropylene, menthol, low-substituted hydrocarbon propyl cellulose, pregelatinized starch, Dextrates NF hydrated, citric acid, polyoxyethylene castor oil, colloidal silica, polyethylene glycol monostearate aliphatic ester, sorbic acid, lemon oil, hydroxypropyl cellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, PEG 4000, PEG 2000, and the like, so as to reduce the side effect of the toxicity caused by acetaminophen to the liver.

Hepatotoxicity-free pharmaceutical composition containing acetaminophen drugs

The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof. The present compound is represented by Formula (II), which has the formula: R&#x2014;O&#x2014;X&#x2014;(CH)&#x2014;X&#x2014;O&#x2014;R, wherein: each X is &#x2014;C(&#x2550;O)&#x2014;; Ris a C-Calkyl polyol: Ris a saccharide group of formula (G); G is a monosaccharide residue, where (i) at least one of the &#x2014;OH groups in (G)is substituted by a halogen atom, and (ii) the saccharide group of formula (G)is linked to &#x2014;O&#x2014; through a &#x2014;CHgroup; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof. The present compound is represented by Formula (II), which has the formula: R&#x2014;O&#x2014;X&#x2014;(CH)&#x2014;X&#x2014;O&#x2014;R, wherein: each X is &#x2014;C(&#x2550;O)&#x2014;; Ris a C-Calkyl polyol; Ris a saccharide group of formula (G); G is a monosaccharide residue, where (i) at least one of the &#x2014;OH groups in (G)is substituted by a halogen atom, and (ii) the saccharide group of formula (G)is linked to &#x2014;O&#x2014; through a CHgroup; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

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Taipei, Taiwan

Tung-Yuan Shih