Cuno, Inc.

Other

Tung-Ping D Liao

Kenneth C Hou

Robert Rohan

The invention is directed to a modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly or indirectly to said polysaccharide, and (b) one or more polymerizable compounds containing (i) a chemical group capable of causing the covalent coupling of the compound (b) to an affinity ligand or a biologically active molecule or (ii) a hydrophobic compound. The invention is also directed to devices for the chromatographic separation of at least two components of a mixture comprising the modified polysaccharide material of the invention, wherein the device is configured for radial or tangential flow.

Affinity matrices of modified polysaccharide supports

A modified silica material which comprises silica covalently bonded to a synthetic polymer, the synthetic polymer being made from (a) a polymerizable compound capable of being covalently coupled directly to said silica, and (b) one or more polymerizable compounds containing (i) an ionizable chemical group, (ii) a chemical group capable of transformation to an ionizable chemical group, (iii) a chemical group capable of causing the covalent coupling of the compound (b) to an affinity ligand or a biologically active molecule or (iv) a hydrophobic compound.

Modified siliceous chromatographic supports

A modified polypeptide material comprising an insoluble polypeptide carrier and synthetic polymer, the synthetic polymer made from (a) a polymerizable compound which has a chemical group capable of covalent coupling to the insoluble polypeptide carrier and (b) one or more polymerizable compounds containing an ionizable chemical group, a chemical group capable of transformation to an ionizable chemical group, a group capable of causing the covalent coupling of the synthetic polymer to an affinity ligand or a biologically active molecule, or a hydrophobic chemical group. The synthetic polymer is covalently bonded to the insoluble polypeptide carrier.

Modified polypeptide supports

A modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly or indirectly to said polysaccharide, and (b) one or more polymerizable compounds containing (i) an ionizable chemcial group, (ii) a chemical group capable of transformation to an ionizable chemical group, (iii) a chemical group capable of causing the covalent coupling of the compound (b) to an affinity ligand or a biologically active molecule or (iv) a hydrophobic compound.

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Vernon, CT, United States of America

Tung-Ping D Liao