Toyo Soda Manufacturing Co., Ltd.

Tuneo Harada

Kiyotaka Oyama

Hisao Takemoto

Tatsuo Igarashi

A process for producing DL-phenylalanine by reacting an .alpha.-halogeno-.beta.-phenylpropionic acid represented by the general formula: ##STR1## where X is a halogen atom, or its salt, with ammonia, characterized in that the reaction is conducted while supplying the .alpha.-halogeno-.beta.-phenylpropionic acid or its salt into aqueous ammonia charged in a reactor in advance.

Process for producing DL-phenylalanine

A process for producing an .alpha.-halogeno-.beta.-phenylpropionic acid represented by the general formula: ##STR1## where X is a halogen atom, which comprises hydrolyzing under heating a halogen-containing ethylbenzene derivative represented by the general formula: ##STR2## where W is a cyano group, an amidocarbonyl group or a lower alkoxycarbonyl group, and X is as defined above, in an aqueous mineral acid solution under vigorous stirring.

Process for producing an .alpha.-halogeno-.beta.-phenylpropionic acid

.alpha.-L-aspartylphenylalanine lower alkyl esters are prepared by a process wherein fumaric acid, ammonia and a lower alkyl ester of L-phenylalanine are contacted with a culture or treated culture of a microorganism belonging to the genus Pseudomonas, and being capable of producing a .alpha.-L-aspartyl-L-phenylalanine lower alkyl ester from fumaric acid, ammonia and a lower alkyl ester of L-phenylalanine.

Process for preparation of aspartylphenylalanine alkyl esters

A process for producing a halogen-containing ethylbenzene derivative represented by the general formula: ##STR1## where X is a halogen atom, and Y is a nitrile group, a carboxyl group, a lower alkoxycarbonyl group or an amidocarbonyl group, which comprises reacting a vinyl compound represented by the general formula:

Process for producing a halogen-containing ethylbenzene derivative

A process for producing a halogen-containing ethylbenzene derivative represented by the general formula: ##STR1## where X is a halogen atom, and W is a nitrile group, a carboxyl group, a lower alkoxycarbonyl group or an amidocarbonyl group, which comprises diazotizing aniline with a nitrite in a solution mixture comprising a hydrophilic organic solvent, an aqueous mineral acid solution and a vinyl compound represented by the general formula:

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Shinnanyo, Japan

Tuneo Harada