Eli Lilly and Company

Tulio Suarez

Edward David Mihelich

C David Jones

Gary A Hite

Nicholas J Bach

Robert D Dillard

Susan Elizabeth Draheim

Jason Scott Sawyer

Daniel Jon Sall

Douglas Wade Beight

Ho-Shen Lin

John Michael Morin, Jr

Jolie Anne Bastian

Michael Enrico Richett

Richard Waltz Harper

Michael LeRoy Phillips

Michael Dean Kinnick

Benjamin Alan Anderson

Robert Theodore Vasileff

Michael Lyle Denney

Nancy Kay Harn

Richard Walter Schevitz

John Mcneill McGill, Iii

David W Snyder

Richard James Loncharich

Peter J Doman

Stuart E Willetts

A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA mediated release of fatty acids for treatment of conditions such as septic shock.

Substituted tricyclics

A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.

Indole sPLA2 inhibitors

A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA,mediated release of fatty acids for treatment of conditions such as septic shock.

A class of novel pyrazoles is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.

Pyrazoles as human non-pancreatic secretory phospholipase A.sub.2

This invention relates to N-hydroxy-N-[3-[2-(4'-halophenylthio)phenyl]prop-2-enyl]ureas, formulations containing those compounds and methods of using such compounds as 5-lipoxygenase inhibiting agents.

N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as

This invention relates to N-hydroxy-N-[3-(2-substituted phenyl)prop-2-enyl]ureas and thioureas, formulations containing those compounds, and methods of using such compounds as 5-lipoxygenase inhibiting agents.

N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas

This invention relates to 2-(substituted)-N-hydroxy-N-alkylcinnamamides of the formula: ##STR1## where R.sup.1 is C.sub.1 -C.sub.4 alkyl;

5-Lipoxygenase inhibitors

Derivatives of 3-phenyl-4-aroyl-1,2-dihydronaphthalenes and 1-aroyl-2-phenylnaphthalenes are useful as antifertility agents.

3-Phenyl-4-benzoyl-1,2-dihydronaphthalenes

Antifertility compounds

Derivatives of 3-phenyl-4-aroyl-1,2-dihydronaphthalenes and 1-aroyl-2-phenylnaphthalenes are useful both as antifertility agents and in suppressing the growth of mammary tumors.

Derivatives of 2-phenyl-3-aroylbenzothiophenes and 2-phenyl-3-aroylbenzothiophene-1-oxides are useful as antifertility agents. Certain of these compounds also are useful in suppressing the growth of mammary tumors.

2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Derivatives of 2-aroyl-3-phenylbenzothiophenes and 2-aroyl-3-phenylbenzothiophene-1-oxides are useful as antifertility agents.

Derivatives of 2-aroyl-3-phenylindenes, 3-aroyl-4-phenyl-1,2-dihydronaphthalenes, and 1-phenyl-2-aroyl-naphthalenes are useful as antifertility agents.

Growing community of inventors

Greenwood, IN, United States of America

Tulio Suarez