Natera, Inc.

Ucl Business Plc

Tudor Pompiliu Constantin

Bernhard Zimmermann

Huseyin Eser Kirkizlar

Styrmir Sigurjonsson

Joshua Babiarz

Matthew Rabinowitz

George Gemelos

Matthew Micah Hill

Onur Sakarya

Lane A Eubank

Allison Ryan

Zachary Demko

Milena Banjevic

Johan Baner

Ryan Swenerton

Raheleh Salari

Robert Charles Swanton

Christopher Abbosh

Bernhard Zimmerman

Solomon Moshkevich

Felipe Acosta Archila

Mariam Jamal-hanjani

Gareth Wilson

Mariam Jamal-Hanjani

The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.

Detecting mutations and ploidy in chromosomal segments

The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

Methods for detection of donor-derived cell-free DNA

The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

Methods for simultaneous amplification of target loci

The invention provides methods for detecting single nucleotide variants in lung cancer, especially stage 3a lung adenocarcinoma and lung squamous cell carcinoma. Additional methods and compositions, such as reaction mixtures and solid supports comprising clonal populations of nucleic acids, are provided.

Methods for lung cancer detection

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Berkeley, CA, United States of America

Tudor Pompiliu Constantin