Lawrence Livermore National Security, LLC

Tuan H Nguyen

Carlos A Valdez

Heather Ann Enright

Brian J Bennion

Nicholas A Be

Felice C Lightstone

Timothy S Carpenter

Margaret Windy McNerney

Hio Leong Lao

Tim Carpenter

Mike Malfatti

Michael A Malfatti

Saphon Hok

Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

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Livermore, CA, United States of America

Tuan H Nguyen