The Hong Kong University of Science and Technology

Other

National University of Singapore

Tsz Kin Kwok

Benzhong Tang

Sijie Chen

Jianzhao Liu

Wei Qin

Yee Yung Yu

Bin Liu

Wing Yip Lam

Ka Ming Ng

Yuning Hong

Anjun Qin

Pengfei Zhang

Wai Tung Leung

Yong Yu

Qian Luo

Dan Ding

Engui Zhao

Kai Li

Haibin Shi

Haiqin Deng

Jingzhi Sun

Meijuan Jiang

Ni Xie

Zheng Zhao

Huifang Su

Chen Gui

Jun Long Geng

Qiuli Zhao

Zhiming Wang

Yueyue Zhao

Ju Mei

Lucia Viglianti

Zhengke Wang

Xiujuan Shi

The present subject matter is directed to a luminogen exhibiting aggregation induced emission, wherein T1, T2, and T3 comprise one or more polyynes as a conjugated bridge. The present subject matter is also directed to an AIEgen comprising a hydrophilic pyridium group as a strong electron-withdrawing group; a piperazine group as an electron-donating group; and a &#x3b1;-Cyanostilbene; wherein the AIEgen exhibits aggregation induced emission. The present subject matter is directed to a method of synthesizing an AIEgen and is further directed to a method of labeling comprising incubating a subject having cells with a conjugate formed by conjugating an AIEgen with an antibody; and selectively labeling desired cells by turn-on imaging, wherein labeling occurs when the desired cells are selectively stained by fluorescent emission of the AIEgen upon degradation of the antibody after cellular internalization of the conjugate through endocytosis.

AIEgens for cancer cell imaging

The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.

Aie luminogens for visualization and treatment of cancer

The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

Biocompatible nanoparticles with aggregation induced emission characteristics as fluorescent bioprobes and methods of using the same for in vitro and in vivo imaging

A photoactivatable caged compound (TPE-C) with AIE characteristics is designed and synthesized. TPE-C is non-emissive either in solution or in aggregated state, but its luminescence can be induced to emit strong cyan emission in aggregated state by UV irradiation. Such property enables TPE-C to be applied in photo-patterning and anti-counterfeiting related areas.

Photoactivatable caged compounds with AIE characteristics: method of preparation and applications

Provided herein are fluorescent bioprobes comprising fluorogens that exhibit aggregation-induced emission (AIE) labeled on biomolecules. The present subject matter relates to a fluorescent bioprobe comprising one or more fluorogen labeled on chitosan. The present subject matter is also directed to methods of preparing the fluorescent bioprobes, methods of labeling and detecting DNA and/or proteins with the fluorescent bioprobe, and methods of cell imaging including live cell tracking.

Aggregation induced emission of fluorescent bioprobes and methods of using the same

Growing community of inventors

Hong Kong, China

Tsz Kin Kwok