Kyowa Hakko Kogyo Co., Ltd.

University of Pittsburgh

Tsuyoshi Yamagata

Akira Karasawa

Kaoru Atsuki

Tetsuji Ohno

Shiro Shirakura

Haruki Takai

Shigeru Aono

Makoto Yoshida

Toshiaki Kumazawa

Shigeki Fujiwara

Koji Suzuki

Naoki Yoshimura

Ken Nagashima

William C De Groat

Shin-ichi Sasaki

Adrian Sculptoreanu

Takashi Seishi

The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein Rrepresents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen;X-X-Xrepresents CR&#x2550;CR&#x2014;CR&#x2550;CR, N(O)&#x2550;CR&#x2014;CR&#x2550;CR, CR&#x2550;CR&#x2014;N(O)&#x2550;CR, CR&#x2550;CR&#x2014;CR&#x2550;N(O), CR&#x2550;CR&#x2014;O, CR&#x2550;CR&#x2014;S, O&#x2014;CR&#x2550;CR, S&#x2014;CR&#x2550;CRor O&#x2014;CR&#x2550;N;Y represents 13 CHS&#x2014;, &#x2014;CHSO&#x2014;, &#x2014;CHSO&#x2014;, &#x2014;CHO&#x2014;, &#x2014;CH&#x2550;CH&#x2014;, &#x2014;(CH)&#x2014;, &#x2014;SCH&#x2014;, &#x2014;SOCH&#x2014;, &#x2014;SOCH&#x2014; or &#x2014;OCH&#x2014;; andRrepresents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic group] or a pharmaceutically acceptable salt thereof.

Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia

The present invention provides a therapeutic agent for overactive bladder comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein Rrepresents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;

Remedies for vesical hyperactivity

The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type Kchannel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type Kchannel opening activity as an index.

Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia

The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I):

Tricyclic compounds

Growing community of inventors

Sunto-gun, Japan

Tsuyoshi Yamagata