Daiichi Sankyo Company, Limited

Ishihara Sangyo Kaisha, Ltd.

Tsuyoshi Ueda

Masayuki Morita

Toru Koyanagi

Taku Hamamoto

Kazuhisa Kiriyama

Tetsuo Yoneda

Tatsuya Nakamura

Yuji Nakamura

Takahiro Haga

Hitoshi Sato

Tatsuya Yamaguchi

Shigeru Noguchi

Hirohiko Kimura

Takahiro Aoki

Yutaka Kitagawa

Shinji Matuura

Akihiro Hisamatsu

Kazutoshi Ukai

Kotaro Yoshida

Toshihiko Ueki

Tadahiro Takeda

Kohei Sakanishi

Yuzo Abe

Kohei Kadota

Mayumi Kanamori

Takashi Kouko

Fumikatsu Kondo

Kei Kurahashi

Yohei Yamane

Crystals of the compound represented by formula (1), a method for the production thereof, and a method for producing an antibody-drug conjugate using the crystals.

Method for producing antibody-drug conjugate

In a method for producing a de-dimethoxybenzylated compound by removing a dimethoxybenzyl group from a compound containing a dimethoxybenzyl group bonded to a nitrogen atom in the presence of an acid, the de-dimethoxybenzylated compound is obtained by removing the dimethoxybenzyl group without forming a poorly soluble product resulting from the removed dimethoxybenzyl group. The de-dimethoxybenzylation reaction is carried out in the presence of triphenylphosphine or diethylthiourea.

Method for removing dimethoxybenzyl group

A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formula, Rrepresents C-Calkyl group or a C-Ccycloalkyl group, Rrepresents a C-Calkyl group or a hydrogen atom, and A represents a fluorous alkyl group (wherein the fluorous alkyl group represents a C-Calkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms).

Method for producing 1-(acyloxy)alkyl carbamate derivative

A method of controlling pest with a pesticidal composition comprising synergistically effective amounts of at least one anthranilamide compound represented by the formula (I) or its salt and other pesticide: wherein each of Rand Rwhich are independent of each other, is halogen; each of Rand Ris halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or cyano; A is alkyl substituted by Y; Y is Ccycloalkyl which may be substituted by at least one substituent selected from the group consisting of halogen, alkyl and haloalkyl; n is 0 or 1; and q is an integer of from 0 to 4; provided that Rand Rare not simultaneously chlorine nor bromine.

Pesticidal compositions

A method for producing a compound (3), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst. 

Methods for producing optically active valeric acid derivatives

An object of the present invention is to provide a novel method for producing a compound, a salt thereof, or a hydrate of the compound or the salt, which is an FXa inhibitor. The object can be attained by a production method in which a production method via a compound represented by formula (1-1), etc., from a compound represented by the following formula (1-x), etc., is used for a method for producing a compound represented by the following formula (X), etc. [wherein X represents a halogen atom or the like, and Rrepresents an optionally substituted phenyl group].

Method for producing inhibitor of activated blood coagulation factor X (FXa)

A pesticidal composition comprising synergistically effective amounts of at least one anthranilamide compound represented by the formula (I) or its salt and other pesticide: wherein each of Rand Rwhich are independent of each other, is halogen; each of Rand Ris halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or cyano; A is alkyl substituted by Y; Y is Ccycloalkyl which may be substituted by at least one substituent selected from the group consisting of halogen, alkyl and haloalkyl; n is 0 or 1; and q is an integer of from 0 to 4; provided that Rand Rare not simultaneously chlorine nor bromine. 

To provide a novel pesticide. The present invention provides a pesticide containing a pyridyl-triazolopyrimidine derivative represented by the formula (I) or its salt as an active ingredient: wherein Ris substitutable alkyl, substitutable cycloalkyl, substitutable alkenyl, substitutable alkynyl, halogen, cyano, aryl, a heterocyclic group which may be substituted by alkyl, OR, S(O)3? or NRR; Ris hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, acetyl or aryl; Ris alkyl or acetyl; Ris hydrogen or alkyl; Ris hydrogen, alkyl or the like; X is alkyl, alkenyl, alkynyl, halogen, haloalkyl, cyano, nitro or the like; m is an integer of from 1 to 4; and n is an integer of from 0 to 2. 

Pyridyl-triazolopyrimidine derivative or its salt, pesticide containing it and its production process

Geometrical isomers of acrylonitrile compounds, mixture thereof, and process for producing these

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Kusatsu, Japan

Tsuyoshi Ueda