Taisho Pharmaceutical Co., Ltd.

Other

Riken Corporation

Tsuyoshi Uchiyama

Katsuhiko Mikoshiba

Teiichi Furuichi

Fumio Yoshikawa

Ariko Imaoji

Fuminori Kimura

Fumio Urushizaki

Haruo Shimamura

Megumi Suzuki

The present invention provides a high affinity polypeptide having a binding activity to inositol 1,4,5-trisphosphate, to a gene encoding the polypeptide, to a recombinant vector including the gene, to a transformant including the vector and to a method for producing the high affinity polypeptide having a binding activity to inositol 1,4,5-trisphosphate.

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Powdery aerosol preparations, which are characterized in that 50 to 90% by weight of a propellant having a vapor pressure at 20&deg; C. of 4.5 kg/cm or less, 5 to 30% by weight of an aliphatic hydrocarbon having a boiling point of 5 to 40&deg; C., 0.5 to 20% by weight of a powdery component and 1 to 20% by weight of a lower alcohol are packed in a container provided with a straight nozzle button having an orifice of 0.7 to 2.0 mm, show improved adhesion of the powders and the active ingredients to the skin and give an excellent feel in using, are provided.

Aerosol powder with improved skin adhesion

Nucleic acids, vectors and transformed cells for making and using high affinity IP-3 binding polypeptides

The present invention is intended to provide a dispenser structure for aerosol containers, which can control the discharge rate of aerosol and ensure satisfactory and safe dispensing of the aerosol while preventing the particle size of the dispensed aerosol from becoming too fine and preventing its excessive scattering which too fine particles would entail. Its structure is characterized in that it includes a dispenser (1) provided with a dispensing guide or first nozzle (11) communicating with a dispensing valve (2); a second nozzle (10) provided within the dispensing guide or first nozzle (11) and having a smaller dispensing port (10a) whose bore d is not more than 0.5 mm; and a larger dispensing port (1a) having a bore b of 0.8 to 3 mm and a length c of not less than 5 mm, formed within the dispensing guide or first nozzle (11) downstream, in the direction of dispensing from the second nozzle (10).

Spouting structure for aerosol vessels

Aerosol preparation

Growing community of inventors

Tokyo, Japan

Tsuyoshi Uchiyama