Nof Corporation

Tsuyoshi Takehana

Ken-ichiro Nakamoto

Chika Itoh

Yuji Yamamoto

Atsushi Sato

Takuma Tsubusaki

Masaki Kamiya

Takashi Ichikawa

Shuichi Yoshimura

Shota Sasaki

Yuichi Takahashi

Akiko Doi

Kosuke Nishiguchi

Toshihiko Hagihara

A method for producing a terminal carboxyl group-containing polyethylene glycol, which includes the following steps 1 and 2. Step 1: In a solution containing a polyethylene glycol having a hydroxyl group, an inorganic base 0.5 to 4 times the polyethylene glycol in mass, an aprotic solvent and water, mass of the water being 5 to 20 meq with respect to the inorganic base and mass of the water in the solution being 2,000 ppm or less, a compound of the formula (1) is reacted with the polyethylene glycol to obtain a polyethylene glycol ester: wherein X represents a leaving group, a represents an integer of 4 to 9, and Rrepresents a hydrocarbon group having 1 to 4 carbon atoms; Step 2: The polyethylene glycol ester is hydrolyzed to obtain a terminal carboxyl group-containing polyethylene glycol.

Method for producing terminal carboxyl group-containing polyethylene glycol and method for producing activated polyethylene glycol

A method for producing polyethylene glycol having a terminal carboxyl group including oxidizing polyethylene glycol represented by formula (I): CHO(CHCHO)(CH)&#x2014;CHO with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from a carbonate, a phosphate, a citrate and an acetate at 5 to 40&#xb0; C. to produce polyethylene glycol represented by formula (II): CHO(CHCHO)(CH)&#x2014;COOH, wherein n is a number from 10 to 1,100, and m is 2 or 3.

Method for producing polyethylene glycol having terminal carboxyl group

There is provided a method for production of a high-purity biodegradable polyoxyethylene derivative on an industrial scale using a polyoxyethylene compound containing polylactic acid at the terminal thereof. A biodegradable polyoxyethylene compound represented by formula (1) and a compound represented by formula (I) are caused to react with each other at 60&#xb0; C. to 120&#xb0; C. using toluene as a solvent in the presence of sodium acetate to obtain a biodegradable polyoxyethylene derivative represented by formula (2).

Method for production of biodegradable polyoxyethylene derivative

A polyfunctional polyoxyalkylene compound represented by the following formula (1): wherein Z represents a hydroxyl group-removed residue of pentaerythritol or dipentaerythritol, R represents a hydrocarbon group having 1 to 24 carbon atoms, OAand OArepresent an oxyalkylene group having 2 to 4 carbon atoms, Land Lrepresent an alkylene group which may have an ester bond or the like in the alkylene chain or at the terminal end, and X represents a functional group capable of reacting chemically; R, OA, OA, L, and Lare the same or different from one another in one molecule, m and n are an average number of moles of the oxyalkylene group added, m represents 5 to 1,000, and n represents 0 to 1,000; p and q represent 0 or 1; r+r=4 or 6; and rand rare an integer of 2 or more.

Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof

A multibranched polyoxyalkylene compound represented by the following formula (1): wherein Ris the same or different and is a hydrocarbon group having 1 to 24 carbon atoms, OAand OAare the same or different and are an oxyalkylene group having 2 to 4 carbon atoms, n and m are the same or different and are an average number of moles of the oxyalkylene group added, n represents 0 to 1000, m is the same or different and represents 10 to 1000, X represents a functional group capable of reacting with an amino group, a mercapto group, an aldehyde group, a carboxyl group, a triple bond, or an azide group to form a chemical bond, and Land Lare the same or different and are a single bond, an alkylene group, or an alkylene group in which at least one bond selected from an ester bond, a urethane bond, an amide bond, an ether bond, and an amino is interposed.

Multibranched polyoxyalkylene compound and producing method thereof

A process for producing a polyalkylene glycol derivative having such high molecular weight and purity that the derivative can be used in pharmaceutical applications, which produces a polyalkylene glycol derivative of the formula (X) by steps (A), (B), (C) and (D), wherein R is as defined:R&#x2014;(OA)OH&#x2003;&#x2003;(X)

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Kanagawa, Japan

Tsuyoshi Takehana