Wyeth

Tsuyoshi Takasaki

Takao Abe

Aranapakam Mudumbai Venkatesan

Atul Agarwal

Yang-I Lin

Koichi Sato

Fuk-Wah Sum

Tarek Suhayl Mansour

Osvaldo Dos Santos

Itsuki Yamamura

Ado Mihira

Hiroshi Matsunaga

Chisato Sato

The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; Ris H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHROCOC1-C6 alkyl; and Ris hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

Bicyclic 6-alkylidene-penems as &#x3b2;-lactamase inhibitors

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is S.

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Saitama, Japan

Tsuyoshi Takasaki