Daiichi Sankyo Company, Limited

Tsuyoshi Soneda

Toshiyuki Konosu

Yoshiko Kagoshima

Nobuhisa Masuda

Koji Matsumoto

Yuko Yamamoto

Hiroshi Takeshita

Takuya Uchida

Junichi Kuroyanagi

Tetsunori Fujisawa

Issei Achiwa

Aki Yokomizo

Takafumi Hosokawa

Tetsuji Noguchi

Naomi Tanaka

Taichi Fukunaga

Shinji Tanaka

Yuji Nakamura

Tetsuya Suzuki

Keiji Saito

Osamu Iwamoto

Katsuyoshi Nakajima

Shoko Yoshida

Hiroyuki Tsuruoka

Nobuyuki Ohkawa

Hidenori Namiki

Nobuya Kurikawa

Wataru Saitoh

Natsumi Nishihama

Shigeo Yamanoi

Momoko Ogitani

Makoto Yamaoka

Jitendra Anant Sattigeri

Yuichi Ochiai

Fuminao Doi

Katsuji Kagechika

Madoka Hoshino

Junya Kawai

Manoj Kumar Khera

Tomohiro Honda

Yuma Umezaki

Hiroki Sakai

Tarun Mathur

Ryo Itooka

Jitendra A Sattigeri

An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof,

Urea compound having substituent

An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: 

Urea derivative

An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. Provided is a pharmaceutical composition containing, as an active ingredient, a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula (I), Rand Rare the same or different, and represent a C-Calkyl group, a halogeno C-Calkyl group or a C-Ccycloalkyl group; n represents 0, 1 or 2; each X represents a C-Calkyl group, a C-Ccycloalkyl group, a halogen atom or the like; and Y represents a hydrogen atom, a C-Calkoxy group, a C-Ccycloalkoxy group or a halogeno C-Calkoxy group.

Amide derivative

Problem to be Solved There is a need for a new antibiotic having a novel mechanism of action which exhibit strong antibacterial activity not only against sensitive bacteria but also against resistant bacteria thereof, and at the same time possesses excellent solubility an a safety profile amenable to human use. Solution to the Problem As a result of intensive research, the present inventors have found that a compound represented by general formula (I), 

Hydroxyalkyl thiadiazole derivatives

The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein Rrepresents a C1-C3 alkyl group, each substituent Rmay be the same or different and may each represent a C1-C3 alkyl group, Rrepresents an optionally substituted pyridyl group or the like, Rand R, which are the same or different, each represent a C1-C3 alkyl group, Rand R, which are the same or different, each represent a C1-C3 alkyl group, and n represents 0 to 3.

Phenylxanthene derivatives

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

Imidazole carbonyl compound

An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.

Growing community of inventors

Fujisawa, Japan

Tsuyoshi Soneda