Ajinomoto Co., Ltd.

Morishita Pharmaceuticals Co. Ltd.

Tsuyoshi Shiio

Shigeyoshi Miyashiro

Takao Kida

Hiroshiro Shibai

Shigezo Udaka

Kunisuke Izawa

Toshihiko Ando

Junji Hamuro

Tetsuo Suami

Kazuo Ohishi

Yasumi Yugari

Kazuo Hirayama

Seiichi Nishi

Asao Murai

Tatsuo Kuoka

Tatsuo Setsuta

Yutaka Iwao

Takashi Yoshihama

Mitsuharu Fujii

Eikou Shimizu

Platinum complexes of cis-diaminocyclohexanol or cis-diaminocyclohexane, with the exclusion of platinum complexes of 2-deoxystreptamine, having high anti-tumor activity, low toxicity, water-solubility and exhibiting no cross-resistance to cis-platin.

Platinum complexes and uses therewith

This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000.

Anthracycline compounds bound to hydrophilic polypeptides

A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.

Streptothricin-group compounds

A high molecular weight peptide antibiotic designated as AN-7D which is effective as an agent.

High molecular weight antitumor antibiotic AN-7D

The glucans and glucan derivatives which inhibit the growth of sarcoma 180 in mice are only sparingly soluble in water, and their aqueous solutions are unstable. In the presence of 0.1 to 1.0 g/dl water soluble dextran, hydroxyethyl starch, carboxymethyl cellulose, or polyethylene glycol, they form relatively concentrated and stable solutions, particularly in the presence of hexoses, pentoses or sugar alcohols having 5 or 6 carbon atoms.

Stable aqueous solutions of glucans and glucan derivatives capable of

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Kamakura, Japan

Tsuyoshi Shiio