Canon Kabushiki Kaisha

Kabushiki Kaisha Toshiba

Taisho Pharmaceutical Co., Ltd.

Tsuyoshi Shibata

Masataka Yashima

Hiromitsu Yamaguchi

Noribumi Koitabashi

Takashi Ochiai

Shinichi Ito

Hitoshi Tsuboi

Eri Goto

Koichi Sato

Kazuo Yoshinaga

Hiroshi Ohta

Toshikazu Ohnishi

Kei Hayasaki

Yomishi Toshida

Takeo Eguchi

Eri Noguchi

Yoshitomo Marumoto

Kenji Kawano

Yasunori Fujimoto

Makoto Akahira

Masato Hayashi

Koji Hashimoto

Seiichiro Karita

Akihiro Mouri

Satoshi Wada

Yuji Kondo

Osamu Kanome

Hiroyuki Ogino

Shuji Yamamoto

Kazunari Sakagami

Yasuhiko Sato

Yoshinori Sekiguchi

Akito Yasuhara

Takeshi Kuwada

Yoshihisa Shirasaki

Kenichi Kawabe

Satoshi Shimizu

Masato Takahashi

Takashi Sato

Makoto Shioya

Katsuhiko Hieda

Yuji Kobayashi

Keiji Horioka

Toshio Nakamura

Yoshinori Tomida

Hajime Sakata

Yasunobu Onishi

Tadahito Fujisawa

Masafumi Asano

Katsumi Aoki

Kenichi Suzuki

Ryoji Fujiwara

Toshihito Kumagai

Taketoshi Okubo

Keiji Ohkoda

Hidehito Takayama

Kazuyuki Maeda

Ayako Nakano

Dai Nozawa

Motoya Kishida

Yuki Shimizu

Makoto Hamada

Takahiro Oi

Ryoki Jahana

Fumihito Ushiyama

Seiji Masuda

Tetsuo Takayama

Fumiyasu Shiozawa

Shoichi Kuroda

Seiji Nakagawa

Yohei Matsuda

Kanako Yamamoto

Yasunobu Ushiki

Fumito Uneuchi

Madoka Kawamura

Naoki Miyakoshi

Daisuke Matsuda

Koutarou Sho

Junko Ohuchi

Kumi Abe

Yuko Araki

Xiang-Min Sun

Takeshi Koami

Hideaki Tabuse

Shuichi Taniguchi

Akira Hiratate

Yuri Amada

Youichi Shimazaki

Kosuke Kanuma

Daizo Mutoh

Hidehisa Mabuchi

Masaru Toda

Chie Koizumi

Sota Kato

Yuri Fujisawa

Noribuma Koitabashi

Jun Idebuchi

Katsuhiko Heida

Eiji Munetomo

The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect:A-Y&#x2003;&#x2003;[1]wherein  

Phenyl tetrahydroisoquinoline compound substituted with heteroaryl

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I&#x2032;),W, Y, R, R, R, and Yare as described hereinabove), or pharmaceutically acceptable salts thereof.

Partially saturated nitrogen-containing heterocyclic compound

Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like. 

Ethinyl-pyrazole derivative

The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder: 

Glycine transporter inhibiting substances

PROBLEM To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. SOLUTION A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I). 

7-piperidinoalkyl-3, 4-Dihydroquinolone derivative

An inkjet printing apparatus prints by ejecting ink on the basis of image data while scanning a printing head, in which ejection openings for ejecting the ink are arranged, over a printing medium in a direction different from a direction of the arrangement of the ejection openings. The inkjet printing apparatus includes a counting unit for counting the number of ink ejections in a predetermined area among a plurality of areas on the basis of image data for each of the plurality of areas, with the plurality of areas being obtained by dividing, in a main scanning direction, a region over which the printing head scans, and a correction unit for correcting the image data included in the plurality of areas on the basis of the number of ink ejections in each of the plurality of areas. In addition, a printing unit prints by driving the printing head on the basis of the corrected image data. The correction unit corrects image data included in a predetermined area on the basis of an added-up value of the number of ink ejections from an area corresponding to a position where the printing head scans, and printing is implemented to the corresponding predetermined area in the scan direction.

Inkjet printing method and inkjet printing apparatus

A multipass printing is performed by setting the print permission ratios, predetermined for the nozzles in adjoining first and second blocks, in a way that satisfies the following conditions (i) and (ii). (i) The print permission ratio in the boundary section between the first and second blocks represents a value between the print permission ratio in the non-boundary section of the first block and that of the second block. (ii) The print permission ratios in the non-boundary sections of the first and second blocks are each set substantively constant. This arrangement allows the print permission ratio to be adjusted among nozzle blocks, thus satisfying the condition that the print permission ratio in a boundary between adjoining nozzles blocks does not change sharply and that the print permission ratio is substantively constant in each of the nozzle blocks. It is possible to suppress 'interband variations', 'seam lines' and &#x201c;intraband variations&#x201d; coincidentally.

Printing apparatus and printing method providing band suppression between nozzle blocks

There is provided an ink jet printing apparatus in which unevenness that may occur at the edges of printing areas can be reduced also for various printing media including unspecified printing media. In the ink jet printing apparatus which uses a print head for ejecting ink and performs printing by scanning a predetermined area on a printing medium with the print head multiple times, the multiple times of scan including a forward scan and a backward scan, the apparatus comprising: a control unit that cases the print head to print patterns each of which is printed through multiple times of scan of the print head and has different portions in a time interval between the multiple times of scan, with different printing ratios for the multiple times of scan; and a setting unit that sets the printing ratios based on the test patterns.

Ink jet recording apparatus and ink jet printing method

A recording apparatus for recording an image on a recording medium by scanning the recording medium with a recording head for discharging ink includes a thinning unit configured to thin data for discharging ink by the recording head on a plurality of areas formed by dividing scanning regions including at least a first scanning region and a second scanning region to be recorded each by one scan of the recording head in the scan direction, and a recording head drive unit configured to discharge ink by driving the recording head based on data which has been thinned by the thinning unit, wherein a boundary between the areas in the first scanning region is located in a different position from that of a boundary between areas in the second scanning region, which is adjacent to the first scanning region, in the scan direction.

Recording apparatus and recording method

It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle

A pattern forming method is disclosed, which comprises forming a photo resist film on a substrate, irradiating the photo resist film with an energy ray to form a desired latent image pattern, placing the substrate on a spacer provided on a hot plate, heating the photo resist film by using the hot plate, and developing the photo resist film to form a photo resist pattern, wherein an amount of irradiation of the energy ray is set such that the amount of irradiation of the energy ray in an exposure region in which a distance between a back surface of the substrate and an upper surface of the hot plate is long is larger than the amount of irradiation of the energy ray in an exposure region in which a distance between the back surface of the substrate and the upper surface of the hot plate is short.

Pattern forming method and a semiconductor device manufacturing method

In a configuration in which a printhead including a plurality of first printing elements for discharging ink droplets and a plurality of second printing elements for discharging ink droplets larger than ink droplets discharged by the first printing elements is used, the first and second plurality of printing elements are divided into multiple blocks in such a manner that the first printing elements belong to one block and the second printing elements belong to another block. The blocks are individually driven in a time-divisional manner. In the time-divisional driving, the block consisting of the plurality of first printing elements is driven first and then the block consisting of the second printing elements is driven.

Inkjet printing apparatus and driving control method

In a multipass printing system, a quality image is printed even when the number of passes is reduced to increase a printing speed. For this purpose, in a multipass printing system which repetitively alternates a printing scan, which causes the print head to eject ink from the nozzles as it moves in the main scan direction, and a feeding operation, which feeds a print medium in a sub scan direction, the feed distance of the print medium is set according to a density of an image being printed on the print medium.

Ink jet printing apparatus and ink jet printing method

A lithography apparatus includes a resist processing apparatus to perform a process of applying a resist on a substrate, a process of heating a resist film on the substrate, and a process of developing the resist film on the substrate, an immersion exposure apparatus including a projection optical system which projects an image of a pattern on a photomask onto the resist film and configured to perform exposure through liquid located on an optical path between the projection optical system and resist film, a transporting apparatus connected to the resist processing and immersion exposure apparatuses to perform transportation of the substrate between the resist processing and immersion exposure apparatuses, and a temperature/humidity control apparatus configured to control at least one of temperature and humidity in at least one of the resist processing and transporting apparatuses based on temperature and humidity or the in humidity the immersion exposure apparatus.

Lithography apparatus, method of forming pattern and method of manufacturing semiconductor device

There is provided an ink jet printing apparatus capable of printing an image having few joining stripes. Dot count is performed regarding an image printed in the vicinity of the joining stripe, and print duty is judged. Next, a dot count value is determined from the print duty. Then, a print data correction rank is determined beforehand in accordance with properties of the printing apparatus, and image data to be printed in the vicinity of the joining stripe is added or thinned out. Thus, an image can be printed which has few black and white stripes.

Image processing method and ink jet printing apparatus

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Yokohama, Japan

Tsuyoshi Shibata