Yoshino Kogyosho Co., Ltd.

Sony Corporation

Takeda Pharmaceutical Company Limited

Mitsubishi Electric Corporation

Shiseido Company, Limited

Sumitomo Pharma Switzerland Gmbh

Tsuyoshi Sasaki

Hiroshi Mizushima

Akinori Fujimura

Kazuhiro Miwa

Koichiro Fukuoka

Fumiya Komura

Kazushige Nigawara

Satoshi Kitayama

Hiroyuki Kato

Shigeo Iizuka

Shigenori Tani

Petinka I Vlahova

Mao Komai

Katsuyuki Motoyoshi

Hiromichi Saito

Toru Toma

Naoki Tsuda

Yoshihiko Kobashi

Akira Ogihara

Patricia Andres

Futaba Ejima

Michael Thomas Brandl

Toshihiro Tashiro

Takefumi Kuriyama

Takafumi Nambu

Kosuke Otaka

Yasuhito Yamamoto

Packaging container

This disclosure relates to novel crystalline forms of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea. It also relates to methods of making the disclosed crystalline forms, pharmaceutical compositions and kits comprising them, and methods of treatment and uses comprising their administration.

Crystalline forms of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrirnidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1'-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

Compositions of thienopyrimidine derivatives

A dispensing container capable of changing the ratio between the amounts of two kinds of contents to be dispensed, includes two container bodies, two pumps including two stems, an adjusting member configured to press the stems and to be rotatable about an axis extending in a substantially vertical direction, and a pressing head configured to, in response to a depressing operation, rotate about an axis extending in a substantially horizontal direction, to thereby depress the stems via the adjusting member. The adjusting member includes a plurality of pressing portions against which the stems are pressed, and when the adjusting member is rotated about the axis, a depressing stroke of the one of the plurality of pressing portions on the side of one of the stems becomes shorter, and a depressing stroke of the other one of the plurality of pressing portions on the side of the other stem becomes longer.

Spouting container

Provided is a communication system including a control station and a satellite repeater capable of forming two or more beams. The control station includes a control unit that classifies the two or more beams into clusters each made up of two or more beams among the two or more beams and allocates different frequencies to the beams belonging to one of the clusters. The satellite repeater includes a channelizer that performs exchanging processing on an input reception signal and outputs the reception signal having undergone the exchanging processing, as a transmission signal. A signal used in the exchanging processing includes a signal obtained by combining signals corresponding to the beams defining the one cluster.

Communication system, repeater, control station, and control method

A foamer dispenser including a mesh filter that is disposed in a mixture flow path of a jet ring to allow a mixture to pass is provided. A connecting flow path area between a liquid flow path and the mixture flow path and a connecting flow path area between an ambient air flow path and the mixture flow path have the relation 2.8&#x2264;S/S&#x2264;3.8, and/or, a smallest flow path area of the mixture flow path is located on an immediately upstream side of the mesh filter, and the smallest flow path area and a flow path area of the mesh filter have the relation 4&#x2264;S/S&#x2264;10.3.

Foamer dispenser, and container with foamer dispenser

Disclosed in the present invention is a pump type dispenser which includes a pump held by a mouth portion of a container and configured to suction and pressure-feed a content liquid in the container, and a nozzle head having an internal passage through which the pressure-fed content liquid passes and driving the pump by being repeatedly pushed down and restored. The internal passage includes a vertical passage, a lateral passage, and a protrusion protruding toward an inner side in a joining portion between the vertical passage and the lateral passage, and a dispensing member disposed in the lateral passage includes a recessed portion which engages with the protrusion to prevent separation from the lateral passage.

Pump type dispenser

In a foamer dispenser, a depressing head includes: a head main unit with a top wall portion arranged above the stem and with an attachment cylindrical portion that extends downwardly from the top wall portion and is attached to the stem; and an exterior cylindrical portion that is provided beneath the top wall portion and surrounds the attachment cylindrical portion and the guide cylindrical portion from an outer side in a radial direction. An inside of the exterior cylindrical portion is communicable with an inside of the cylinder for air through an inside of the guide cylindrical portion. The head main unit and the exterior cylindrical portion are formed as separate entities and are fitted to each other. In an upper end portion of the exterior cylindrical portion, intake holes are formed that penetrate through the exterior cylindrical portion in a radial direction and open toward an upward direction.

Foamer dispenser

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethyl aminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1'-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

Production method of thienopyrimidine derivative

A foamer dispenser includes a hollow stem, an air piston configured to pressurize and pump air, and a tubular guide that is coupled integrally to the air piston, that defines an airway for air supply between the hollow stem and the tubular guide, that holds the hollow stem slidably, and that is configured to come out of abutment with the flange in response to sliding of the hollow stem, thereby opening the airway is provided. The flange is provided with: an outer annular wall protruding upward from an outer edge of the flange; and a guide rib located on an outer side of the tubular guide in the radial direction and configured to be guided by the tubular guide during sliding of the hollow stem.

A dispensing container that dispenses a liquid contained therein in foam includes: a container body storing therein a liquid; and a base cap mounted to a mouth of the container body. The container body is flexible so that a squeeze operation may be performed on the container body. The base cap is provided, on a top wall, with a nozzle forming a tubular passage communicating with a front end orifice. The nozzle is provided with a foaming mechanism for the liquid at an upstream end portion and with a through-hole in a predetermined position on a circumferential wall of the nozzle that is downstream of the foaming mechanism. The through-hole is provided with a check valve, and the front end orifice communicates with an inside of the container body through the through-hole.

Dispensing container

A reply apparatus includes: a reception analog switch matrix that outputs, to reception processing units, a wideband reception signal in a band wider than the bandwidth processable by the reception processing unit; a connecting unit that outputs demultiplexed signals to transmission processing units; a transmission analog switch matrix that outputs, to the same transmission antennas, signals subjected to transmission processing; a local generating unit that generates and transmits local signals having different frequencies to the reception processing units; a local-phase-difference calculating unit that calculates a phase difference between the local signals and inputs the phase difference to the reception processing units; and reception-phase correcting units that perform phase correction on the basis of the phase difference. The reception processing units, when the wideband reception signal is input, apply reception processing to divided signals obtained by extracting a part of bands of input signals on the basis of the local signals.

Relay apparatus, relay satellite, and satellite communication system

A bottle shape is provided that allows for volume-reducing deformation of a peripheral wall of the body, while maintaining stable posture of the bottle by making use of a combination of a refill container and a regularly used container having an upright discharge cylinder segment. The body is formed to have a thin peripheral wall so that volume-reducing deformation would take place along with the depressurization going on inside the bottle. The peripheral wall has three ridge lines formed in a mountain fold at approximately equal intervals in the vertical direction and has three panel walls connected to one another. Each panel wall is bordered by two adjacent ridge lines, and has a valley fold line that diagonally connects an upper end of one ridge line to a lower end of another adjacent ridge line so that three valley fold lines are disposed obliquely in parallel along a circumferential direction.

Synthetic resin bottle, and a combination of regularly used container and refill container

A photoelectric converter with improved charge transfer efficiency from a light receiving portion. The photoelectric converter includes a light receiving portion having an output end and a gate portion having a first side and a second side that both define a readout gate width for the light receiving portion, where the first side of the gate portion confronts the output end of the light receiving portion. The photoelectric converter also includes a charge transfer portion formed to confront the second side of the gate portion, where the readout gate width of said gate portion is wider at the first side confronting said light receiving portion than at the second side confronting said charge transfer portion.

Growing community of inventors

Tokyo, Japan

Tsuyoshi Sasaki