Kirin Beer Kabushiki Kaisha

Kyowa Hakko Kirin Co., Limited

Tsuyoshi Nishitoba

Yasunari Fujiwara

Tatsushi Osawa

Terufumi Senga

Atsushi Miwa

Kazuhide Nakamura

Kazuo Kubo

Toshiyuki Shimizu

Hideko Murooka

Shinichiro Kato

Janak Padia

Michael Hocker

Hirohi Ohashi

Eiji Sawa

Shinichi Ohyama

Yoshiko Kobayashi

An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X&#x2550;CH or N; Z&#x2550;O or S; L=O or S; M=CRR, wherein Rand R&#x2550;H, alkyl, or alkoxy, NRwherein R&#x2550;H or alkyl; R, R, and R&#x2550;H or optionally substituted alkoxy; R&#x2550;H; R&#x2550;H, halogen, alkoxy or the like; and R=alkyl optionally substituted by &#x2014;R, -T-R, or &#x2014;NRRwherein T=O, S, or NH; R=an optionally substituted carbocyclic or heterocyclic ring; and R=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or &#x2014;NRRwherein Rand R&#x2550;H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same

An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CRR, wherein Rand R=H, alkyl, or alkoxy, NRwherein R=H or alkyl; R, R, and R=H or optionally substituted alkoxy; R=H; R=H, halogen, alkoxy or the like; and R=alkyl optionally substituted by &#x2014;R, -T-R, or &#x2014;NRRwherein T=O, S, or NH; R=an optionally substituted carbocyclic or heterocyclic ring; and R=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or &#x2014;NRRwherein Rand R=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same

Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thiourea derivatives can be synthesized using liquid and solid phase synthesis protocols.

Urea derivatives as inhibitors for CCR-3 receptor

Quinoline and quinazoline derivatives inhibiting platelet-derived growth

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Tokyo-to, Japan

Tsuyoshi Nishitoba