Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Bio Co., Ltd.

Tsuyoshi Mokudai

Hirofumi Nakano

Isao Kawamoto

Eiji Kobayashi

Mayumi Yoshida

Mitsunobu Hara

Hideki Murata

Michio Shiomi

A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline.

Method of purifying cytidine diphosphate choline

Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.

DC115A compounds produced by streptomyces sp.

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Hofu, Japan

Tsuyoshi Mokudai