Nof Corporation

Nippon Oil Fats Co., Ltd.

Tsuyoshi Miyazaki

Akinori Suginaka

Shigeru Kitano

Tohru Yasukohchi

Yoshishige Murata

Kouzoh Sanchika

Yoshihito Kadoma

Yoshiyuki Koyama

Mitsuhiro Nishida

Masayuki Yokoyama

Kazunori Kataoka

Yasuhisa Sakurai

Yasumi Koinuma

Takeo Matsumoto

Shuji Ichikawa

Kazuo Matsuyama

Koji Kamenosono

Motoharu Iwatsuru

Shuji Kojima

Kazuo Maruyama

Hiromitsu Nakajima

Yoshihiro Minoshima

Kazunori Waki

Daijiro Shiino

A first prepolymer contains a structural unit represented by the formula ##STR1## where m denotes a positive number of from 2 to 20 with a polymerization degree of 2 to 1000. A second prepolymer contains a structural unit represented by the formula ##STR2## where X denotes a hydrogen atom or a halogen atom, m.sup.1 and m.sup.2 denote positive numbers of from 2 to 20 and n.sup.1 +n.sup.2 denote positive numbers of from 2 to 1000, with n.sup.1 and n.sup.2 being not equal to 0, the prepolymer having a polymerization degree of 2 to 1000. An optical material with a high refractive index is obtained by polymerizing and curing a polymerizable composition containing the first or second prepolymer.

Alkylene sulfide group-containing prepolymer, polymerizable composition

A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

Reactive vesicle and functional substance-fixed vesicle

The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

Polymers having benzeneboronic acid groups and insulin complexes of same

A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.

Phospholipid derivative and reactive vesicle-forming agent

The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

Polymer-drug conjugate and a method of producing it

Growing community of inventors

Tsukuba, Japan

Tsuyoshi Miyazaki