Sumitomo Chemical Company, Limited

K.k.endo Seisakusho

Tsuyoshi Kobayashi

Hisao Yamamoto

Shigeho Inaba

Yoshiaki Takebayashi

Junki Katsube

Kikuo Sasajima

Katsumi Tamoto

Kikuo Ishizumi

Michihiro Yamamoto

Isamu Maruyama

Kazuo Mori

Toshiyuki Hirohashi

Tadashi Okamoto

Katsutoshi Maruyama

Takashi Yaoita

Tsuyoshi Saito

Shinichi Kaneko, Deceased

Provided is a fixing sleeve making it possible to reduce the surface roughness of the inner circumferential surface of the fixing sleeve by spinning, and a method for manufacturing the fixing sleeve. The spinning is performed by moving rollers, in the axial direction of a cup-shaped tubular body and, at the same time, a burnishing tool (spherical tool) is pressed against the outer circumferential surface of the cup-shaped tubular body after the spinning, and the burnishing tool is moved in the same direction as the rollers. The cup-shaped tubular body is plastically deformed in the axial direction of the cup-shaped tubular body, reduced in wall thickness, and elongated in the axial direction.

Fixing sleeve and manufacturing method thereof

Novel benzisoxazole compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, ar(C.sub.1 -C.sub.3)alkoxy or halogen or, when taken together, they form C.sub.1 -C.sub.2 alkylenedioxy, Alk is C.sub.1 -C.sub.4 alkylene and A is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each C.sub.1 -C.sub.4 alkyl or, when taken together with the adjacent nitrogen atom, they represent a 5-6 membered nitrogen-containing heterocyclic ring which may contain any additional hetero atom and R.sub.5 is C.sub.1 -C.sub.4 alkyl or aryl), and non-toxic salts thereof, which possess various pharmaceutical activities.

Benzisoxazole derivatives

Novel benzisoxazole compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, ar(C.sub.1 14 C.sub.3) alkoxy or halogen or, when taken together, they form C.sub.1 -C.sub.2 alkylenedioxy, Alk is C.sub.1 -C.sub.4 alkylene and A is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each C.sub.1 -C.sub.4 alkyl or, when taken together with the adjacent nitrogen atom, they represent a 5-6 membered nitrogen-containing heterocyclic ring which may contain any additional hetero atom and R.sub.5 is C.sub.1 -C.sub.4 alkyl or aryl), and non-toxic salts thereof, which possess various pharmaceutical activities.

3-(Piperazinoalkyl)-benz-2,1-isoxazoles

Ortho-acylated anilide derivatives represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each C.sub.1 - .sub.3 alkyl, and n is 1 or 2, and salts thereof.

Ortho-acylated anilide derivatives and salts thereof

A 1-alkyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is produced by contacting a 1-aminoethyl-indole derivative with a suitable oxidizing agent and then reducing the resulting 1-acyl-2,3-dihydro-1H-1,4-benzodiazepine derivative. The starting 1-aminoethyl-indole derivative is prepared by subjecting a 3-phenyl-indole derivative to cyanomethylation (or carbamoylemethylation) and then reducing the resulting 1-cyanomethyl- (or 1-carbamoylmethyl)-indole derivative. The 1-acyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is useful as a tranquillizer, muscle-relaxant, etc.

Preparation of benzodiazepines

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Niigata, Japan

Tsuyoshi Kobayashi