Sankyo Company, Limited

Tsuyoshi Hosoya

Kouhei Furuya

Nobufusa Serizawa

Tatsuji Matsuoka

Masaaki Takahashi

Masami Miura

Noriyoshi Uchida

Shuji Takahashi

Atsushi Hattori

Kazuhiko Tanzawa

Kaneo Ogawa

Mitsuyo Takahashi

Isolated cultures of Pestalotiopsis funerea IFO 5427 and Pestalotiopsis neglecta FERM BP-3501 are provided. The cultures produce a glucoamylase which digests starch.

Isolated cultures of Pestalotiopsis funerea IFO 5427 and Pestalotiopsis

Compounds of formula (I): ##STR1## (wherein R represents a hydrogen atom or an acetyl group), which we have named 'the adenophostins', and, have the ability to increase intracellular calcium ion concentrations by acting on the inositol 1,4,5-trisphosphate (InsP.sub.3) receptors which exist in the endoplasmic reticulum. The adenophostins are useful as hypertensive agents. They can be prepared by cultivation of a microorganism of the genus Penicillium, e.g. Penicillium brevicompactum SANK 11991 (FERM BP-3499) or Penicillium brevicompactum SANK 12177 (FERM BP-3500).

Adenophostins

Trans-4-hydroxy-L-proline is produced microbially, especially by the cultivation of a microorganism of the genus Clonostachys, Gliocladium or Nectria.

Isolated cultures of microorganisms of Clonostachys Cylindrospora,

Microbial process for the production of trans-4-hydroxy-L-proline

Growing community of inventors

Tsukuba, Japan

Tsuyoshi Hosoya