Daiichi Sankyo Company, Limited

Exelixis, Inc.

Tsuyoshi Homma

Raju Mohan

Matthew A Williams

Richard Martin

John M Nuss

Kazumasa Aoki

Tie-Lin Wang

Hiroyuki Tsuruoka

Noriyuki Hayashi

Makoto Mizuno

Keiji Saito

Kiyoshi Arai

Yusuke Asoh

Masatoshi Honzumi

A pharmaceutical for the prophylaxis or treatment of hypertension or a disease derived from hypertension. The pharmaceutical is characterized by comprising (i) a specific mineralocorticoid receptor antagonist and (ii) one or more components selected from the following components (A) to (C), for administration simultaneously or separately at a time interval: (A) an angiotensin II receptor antagonist, (B) a calcium antagonist, and (C) a diuretic.

Pharmaceutical for prophylaxis or treatment of hypertension

The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein Rrepresents a C1-C3 alkyl group; Rrepresents a hydroxy-C1-C4 alkyl group and the like; Rrepresents a halogeno group, a halogeno-C1-C3 alkyl group and the like; Rrepresents a hydrogen atom, a halogeno group and the like, &#x2014;Rrepresents a sulfamoyl group or a C1-C3 alkylsulfonyl group; Rrepresents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing. 

1-phenylpyrrole derivatives

The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein Rrepresents a C1-C3 alkyl group; Rrepresents a 2-hydroxy-C4-C6 alkyl group; Rrepresents a halogeno group, a halogeno-C1-C3 alkyl group and the like; Rrepresents a hydrogen atom, a halogeno group and the like; Rrepresents a C1-C3 alkyl group; and Rrepresents a hydrogen atom, a halogeno group and the like] or atropisomers thereof. 

Atropisomers of (hydroxyalkyl) pyrrole derivatives

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Tokyo, Japan

Tsuyoshi Homma