Shionogi & Company Limited

Sekisui Chemical Co., Ltd.

Sakuranomiya Chemical Co., Ltd

Neomax Materials Co., Ltd.

Tsuyoshi Hasegawa

Hiroyuki Kai

Juichi Fukatani

Masaaki Ishio

Yoshimitsu Oda

Nobuhiro Haga

Masanao Inagaki

Yoshinori Tamura

Shin-ichiro Hara

Yoshihisa Goto

Yukio Tada

Kenji Nakahara

Toshio Tada

Kouki Fuchino

Takeshi Endoh

Genta Tadano

Ken-ichi Kusakabe

Takayuki Kameyama

Syuhei Yoshida

Masaki Matsudo

Miho Oohara

Takuya Shintani

Akira Iida

Takashi Shinjo

Yasuhiko Fujii

Tohru Horiguchi

Takeo Kuroda

Kentaro Asahi

Takeshi Miyake

Yoichi Kitamura

Masanori Matsuda

Toshikatsu Maki

Yoshiyuki Asai

Masao Yamazaki

Sae Jikihara

Ken'ichiroh Nakamura

The present invention provides a compound which has an effect of inhibiting amyloid &#x3b2; production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid &#x3b2; proteins. A compound of the formula (I): wherein X is &#x2014;C(R)(R)&#x2014;, &#x2014;C(R)(R)&#x2014;C(R)(R)&#x2014; or &#x2014;C(R)&#x2550;C(R)&#x2014;, Ris substituted or unsubstituted alkyl or the like,

Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity

The present invention provides a novel P2Xand/or P2Xreceptor antagonist. A compound represented by the formula (I): wherein R, Rand Rare,

Triazine derivative and pharmaceutical composition comprising the same

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein Rand Rare each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., Ris hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., Ris hydrogen or lower alkyl, Ris hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl,or a pharmaceuticallyacceptablyacceptablesalt, or a solvate thereof is provided.

6,7-unsaturated-7-carbamoyl substituted morphinan derivative

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I):

The present invention provides a compound which has an effect of inhibiting amyloid &#x3b2; production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid &#x3b2; proteins. A compound of the formula (I): 

The present invention provides a novel P2Xand/or P2Xreceptor antagonist. A compound represented by the formula (I): 

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein Rand Rare each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., Ris hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., Ris hydrogen or lower alkyl, Ris hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl,or a pharmaceutically acceptably salt, or a solvate thereof is provided.

The present invention provides an interlayer for laminated glass which comprises at least one layer composed of an opaque ethylene-vinyl acetate copolymer resin composition or opaque polyvinyl acetal resin composition, and also provides the laminated glass using such interlayers. The interlayer for laminated glass and the laminated glass according to the present invention can offer excellent privacy protection.

Interlayer for laminated glass and laminated glass

Disclosed are a coating material for metal wherein a thin coating film without pinholes having excellent corrosion resistance, retort resistance, impact resistance, processing resistance, abrasion resistance, adhesiveness to a metal, flavor preservability for contents etc can be formed when applying on a metal plate or a metallic container, and a metallic container on which the coating material is applied. The coating material for metal includes thermoplastic resin particles having an average primary particle size of 10 to 800 nm obtained by cooling a solution of the thermoplastic resin. A process for preparing the coating material for metal comprises steps of (a) obtaining a solution wherein a thermoplastic resin is dissolved into an organic solvent, (b) obtaining a dispersion of particles of the thermoplastic resin having an average primary particle size of 10 to 800 nm by cooling the solution, (c) separating particles from the dispersion and (d) dispersing the separated particles in a solvent.

Process for preparing a metal coating material comprising condensation polymerized resin nanoparticles

A laminated glass and an interlayer film for laminated glasses are provided, which have the high performance for mitigating the impact given externally and, particularly in the case of using it as glass for vehicles, and which have the high performance for mitigating the impact when a person's head comes into collision with the glass due to the occurrence of a personal accident. Also provided is a laminated glass, wherein at least an interlayer film for laminated glasses and a glass sheet are laminated and unified, Head Injury Criteria (HIC) values, measured according to regulations of European Enhanced Vehicle-safety Committee; EEVC/WG 17, being 1,000 or lower.

Laminated glass and interlayer film for laminated glasses

It is an object of the present invention to provide a laminated glass and an interlayer film for laminated glasses, which have the high performance for mitigating the impact given externally and, particularly in the case of using it as glass for vehicles, have the high performance for mitigating the impact when head comes into collision with the glass due to the occurrence of a personal accident. The present invention is directed to a laminated glass, wherein at least an interlayer film for laminated glasses and a glass sheet are laminated and unified, Head Injury Criteria (HIC) values, measured according to regulations of European Enhanced Vehicle-safety Committee; EEVC/WG 17, being 1,000 or lower.

Laminated glass and intermediate film for laminated glass

Hot melt adhesive of cationic polymerizable compound, photoinitiator and phthalate diester

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Osaka, Japan

Tsuyoshi Hasegawa