Mochida Pharmaceutical Co., Ltd.

Ricoh Company, Ltd.

Lattice Technology, Inc.

Toyota Jidosha Kabushiki Kaisha

Fujitsu Corporation

Dainippon Screen Mfg. Co., Ltd.

Mitsubishi Paper Mills Limited

Tsuyoshi Harada

Kiyoshi Mizuguchi

Koji Tanaka

Hiroyuki Kawano

Masayuki Ichioka

Hideo Kanehiro

Atsushi Osada

Takashi Yano

Tomohiro Yamada

Hiroshi Matsuoka

Jun Urasaki

Eiji Miyasaka

Sadao Kuriu

Makoto Yajima

Kyonosuke Yamamoto

Masaharu Kimura

Kouichi Konno

Yoshikazu Takano

Akira Kunihiro

Hisashi Takahashi

Shintaro Nakayama

Hiroshi Toriya

Yasuhiro Kawaguchi

Kunihiro Tanabe

Ayumi Sato

Yoko Wakabayashi

Akira Wakita

Kazumasa Matsukawa

Shun Shirakawa

Fumito Fukuhara

Ayako Suzuki

The disclosure provides for a method for treating a fatty liver disorder in a subject in need thereof, comprising selecting a subject having or suspected of having a fatty liver disease or disorder, wherein the subject is non diabetic, pre-diabetic, mildly diabetic, or has normal or substantially normal biliary tract function; and administering a therapeutically effective amount of a pharmaceutical composition comprising ethyl eicosapentanoate (EPA-E). In some cases EPA-E present may be at least 40% by weight in total of the fatty acids and their derivatives.

Compositions and methods for treating non-alcoholic steatohepatitis

Compositions and method are disclosed comprising ethyl icosapentate for use in treatment of non-alcoholic steatohepatis (NASH).

The disclosure provides for a method for treating a fatty liver disease or disorder in a subject in need thereof, comprising selecting a subject having or suspected of having a fatty liver disease or disorder, wherein the subject is non diabetic, pre-diabetic, mildly diabetic; has normal or substantially normal biliary tract function; or has non or early stage hepatocyte apoptosis; and administering a therapeutically effective amount of a pharmaceutical composition comprising EPAs.

Compositions and method are disclosed comprising ethyl icosapentate for use in treatment of non-alcoholic steatohepatitis (NASH).

Disclosed is a novel NASH marker for use in a method for detecting NASH or evaluating the severity of NASH, which utilizes at least one factor selected from the group consisting of an IL-1 receptor antagonist, sCD40, HMGB1, sPLA2 group IIA and an sPLA2 activity as the marker. Also disclosed is a method for detecting NASH or evaluating the severity of NASH in a subject, which utilizes the marker.

Marker associated with non-alcoholic steatohepatitis

A route data collection method includes: a transmission source apparatus transmitting a request packet to request at least layer-2 apparatuses on a route to a destination apparatus to reply a response packet including predetermined setting data of the layer-2 apparatus to the transmission source apparatus; upon receiving the request packet, the layer-2 apparatus that can respond to the request packet, reading out the predetermined setting data stored in a storage device of the layer-2 apparatus, transmitting the response packet including the predetermined setting data to the transmission source apparatus, and outputting the request packet to the destination apparatus; and upon receiving the response packet, the transmission source apparatus displaying the predetermined setting data included in the response packet on a display device.

Route data collection technique in network

A method and a system are disclosed for enabling an automatic creation of a parts list and 3-dimensional illustrations of a product based on 3-dimensional CAD or XVL data of an industrial product consisting of a plurality of parts. A method for generating a parts catalog consisting of a parts list and corresponding disassembly illustrations is provided. This method comprises the steps of (a) assigning reference numerals/symbols based on the parts list; (b) building a disassembly algorithm based on the parts list; and (c) generating disassembly illustrations based on the disassembly algorithm, wherein minimum disassembly units of the disassembly illustrations are parts and parts groups assigned with the reference numerals/symbols, and displaying the reference numeral/symbol for each of the parts and parts groups in the disassembly illustrations.

Method and system for creating a product parts catalog

In order to circumvent the problems above, the present invention aims to expand the scope of the usage of the information included in three-dimensional shape data by acquiring the shape information included in the three-dimensional shape data automatically on a shape element basis and setting linkages across the acquired information. Linked processing can be performed across the corresponding shape information having different shape elements by adding a linkage identifier to the shape information when generating the shape information from the three-dimensional shape data. For example, when processing for a single shape information is carried out, other shape information can be edited by linkage.

System for acquiring profile information from three-dimensional profile data, its method and computer software program

The objective of the present invention is to provide a method for approximating and displaying a three-dimensional object represented by CAD data. In particular, the present invention provides a method for approximating CAD data representing a three-dimensional object, comprising steps of: (a) generating a mesh with mesh lines for approximating each face of the three-dimensional object represented by the CAD data within a rough conversion tolerance with respect to a specified conversion tolerance; (b) approximating a boundary edge surrounding and defining each individual face with a plurality of curves within the specified conversion tolerance, approximating each of the curves with a polyline comprising points and connecting lines within the rough conversion tolerance to define boundary points which are the points of the polylines, and obtaining a vector tangential to the curve at each of the boundary points; (c) generating polygons with three or four vertices by connecting internal points which are points of intersection of the mesh lines inside the boundary edge, and by connecting the boundary points and the internal points that are adjacent to and inside the boundary edge; (d) calculating a vector normal to the face at each of the vertices of each of the polygons, storing information identifying the vertices and the corresponding normal vectors, and storing the tangential vector at each of the boundary points obtained at the step (b); (e) converting each of the polygons with three or four vertices to a triangular or quadrilateral surface by using a plurality of control points obtained by processing the information identifying the vertices, the normal vectors, and the tangential vectors; and (f) examining if each of the triangular or quadrilateral surfaces is close to the face represented by the CAD data within the specified conversion tolerance, and if not, regenerating a mesh with a narrower mesh width and more mesh lines on the face to repeat the steps (c)-(e) and (f). It is preferable that the polygons are triangles.

System for approximating and displaying three dimensional CAD data, and system for executing method thereof

A method of generating a free-form surface model includes the steps of applying linear transformation to a lattice polygon model to generate vertices of a free-form surface model corresponding to respective vertices of the lattice polygon model, and generating control points of cubic Bezier curves that connect the vertices of the free-form surface model, and that correspond to respective edges of the lattice polygon model.

Generation of free-form surface model by reversible rounding operation

The apparatus for coating a photosensitive material (M) with a processing liquid comprises an activator coating mechanism (43) for metering a constant amount of activator to apply the metered activator to the photosensitive surface of the photosensitive material fed by the pair of introduction rollers. The activator is supplied form a plurality of discharge holes (121) bored in a pipe (122) and is once received by a receiving portion (124). The activator is diffused horizontally and flows downwardly through a plurality of openings (123) bored at the bottom of the receiving portion onto a coating roller (125). The activator is diffused again at the contact between the coating roller and a diffusion film (126) and is coated to the photosensitive material by the coating roller.

Apparatus for processing photosensitive material

The current invention discloses the method and the system for designing a three-dimensional model object with an automatic updating feature which correctly and efficiently updates the model object in response to a modification command. In order to efficiently access a part of the object data associated with the modification command, a group of parts in the model object is referred by an index. Such groups include a face set, an edge sequence and a vertex, and these elements are associated to a given modification command by the index. The association between the modification command and the elements via the index provides an efficient yet flexible access to the relevant object data and substantially eliminates the unintended effects during the updating process.

Method and system for indexing three-dimensional solid model data based

A 3-dimensional (3-D) Computer Aided Design (CAD) System generates a fillet surface which smoothly connects two surfaces to each other. This is accomplished by sliding a circle on a normal plane of a user-designated spine curve which is in contact with two surfaces. Then, the fillet surface is approximated by Gregory patches which are generated from trajectories of two tangent points between the circle and the two surfaces. The fillet surface thus expressed by the Gregory patches is easily and efficiently processed in computers such as those in 3D CAD systems. Because the fillet surface is generated along the spine curve, various fillet surfaces, including that generated by the conventional rolling-ball blending method, can be generated to satisfy various needs of designers of 3-D CAD Systems.

Growing community of inventors

Tokyo, Japan

Tsuyoshi Harada