Canon Kabushiki Kaisha

Nippon Kayaku Kabushiki Kaisha

Tsuyoshi Fukuda

Hidehiko Fukahori

Masaharu Nakamura

Yasuhiro Toyoda

Masayuki Suzuki

Ryuichi Kobayashi

Masayoshi Kiuchi

Shoji Kaihara

Kenji Yokoyama

Chihiro Watanabe

Ken Yamakawa

Yusaku Kikuchi

Toshio Matsumoto

Yoshihiko Aihara

Takuya Kato

Noboru Tanaka

Tatsuo Konno

Fumio Shimada

Keiichirou Yamamoto

Osamu Miyazaki

Yuki Kawano

Dai Kurihara

Kazuya Okamoto

A DDS preparation of a platinum complex, which selectively releases a highly active platinum complex in cells that are under reducing conditions, and exhibits high antitumor activity that is required from a medicine, is still not available, and there is a demand for a novel DDS preparation of a platinum complex that may be used in clinical fields. There is provided a polymer conjugate of a hexa-coordinated platinum complex, the polymer conjugate comprising a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; and a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, the hexa-coordinated platinum complex being bonded, directly or via a spacer, to a side-chain carboxyl group of the block copolymer.

Polymer conjugate of hexa-coordinated platinum complex

According to the present invention, there is a demand for novel platinum(IV) complex which has sufficient water-solubility, stability, antitumor activity, and the like that are required as a medicine, and may be used clinically. Thus, provided is a platinum(IV) complex represented by the following General Formula (I) [wherein Xand Xeach represent a halogen atom or are bonded together to form a dicarboxylate selected from the group consisting of oxalate, malonate, succinate, and o-phthalate; and Y represents a halogen atom. 

Platinum (IV) complex

Provided is a polymeric micelle type DDS preparation that may efficiently exhibit pharmacological activity effects by enhancing migration characteristics, penetrability, and retention characteristics toward a diseased target tissue such as a tumor tissue or an inflammation-affected tissue, and thereby enhancing the action of a pharmacologically active substance. Disclosed is a block copolymer (A) having a hydrophilic polymer segment linked to a hydrophobic polymer segment, the hydrophilic polymer segment containing a polyethylene glycol chain, and the hydrophobic polymer segment containing a polyamino acid chain having a hydrophobic substituent in a side chain, wherein the hydrophilic polymer segment has a target binding site bonded thereto, and the main chain polymer combining the polyethylene glycol chain and the polyamino acid chain has a molecular weight of not less than 2 kilodaltons and not more than 10 kilodaltons.

Active-targeting-type polymer derivative, composition containing said polymer derivative, and uses of said polymer derivative and said composition

A DDS preparation of a platinum complex, which exhibits a superior antitumor effect required as a medicine and reduced side effects, that is, a clinically usable DDS preparation of a platinum complex, which is conjugated to a polymer carrier that is different from conventional carriers, is desired. Provided is a polymer conjugate of a platinum(II) complex, the polymer conjugate including: a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; a sulfoxide derivative introduced into a side-chain carboxyl group of the block copolymer; and a platinum(II) complex coordinate-bonded to a sulfoxide group of the sulfoxide derivative.

Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex

An image sensing apparatus comprises an image sensing unit which receives an object image via a lens and accumulate the received image as an electric charge, a mechanical shutter unit which travels so as to shield an image sensing region of the image sensing unit against light, a scanning unit which performs scanning for sequentially starting the accumulation of the electric charge for each image sensing region of the image sensing unit, a control unit which controls the accumulation start scanning of the scanning unit and the travel of a shutter of the mechanical shutter unit, so as to implement a first curtain and second curtain of a shutter and a changing unit which changes a maximum shutter speed on the basis of one of a type of the lens and information on the lens.

Image sensing apparatus with settable minimum exposure time and control method thereof

In an electronic camera, during a photographing operation for photographing a white sheet of paper or the like to obtain white balance data, a plurality of distance measuring points provided in an automatic focusing mechanism are restricted to only the one that is located at a central portion of the image plane. Further, a determination level used for determining an in-focus state in the automatic focusing mechanism is set lower than where an ordinary object is photographed. Accordingly, the photographing operation for obtaining white balance data can be completed for a short time. Furthermore, if the automatic focusing operation itself is inhibited during the photographing operation for photographing a white sheet of paper or the like to obtain white balance data, that photographing operation can be completed for a very short time.

Electronic camera having a focusing circuit for performing a plurality of focusing operations on the basis of an in-focus level and/or an image area

Electronic camera

A camera includes a lens holding member for detachably holding a lens device, an image taking device for taking an image formed by the lens device, a front main body member forming a front portion of the main body of the camera, a rear main body member which forms a rear portion of the main body of the camera and is coupled to the front main body member, and a central main body member on which the lens holding member and the image taking device are mounted and which is coupled to at least one of the front and rear main body members.

Camera

In an optical apparatus having a mount adapted to be rotated to be attached to and detached from a mount of another apparatus, the mount of the optical apparatus is molded by plastic material, and concave and convex portions are provided on an abutment surface of the mount of the optical apparatus to reduce the sliding area, thereby making the scratches caused by the sliding inconspicuous.

Optical apparatus

A camera including a camera body and flash unit, in which the camera includes a drive source in the camera body, a moving mechanism for causing the flash unit to move from a non-projected position to a projected position, an illumination-angle switching mechanism for varying an illumination angle of the flash unit, the illumination-angle switching mechanism being driven by a force of the drive force in one direction and being capable of stopping in any one of a plurality of specific illumination angle states, a focal length detecting device, and a controlling device that causes the illumination-angle switching mechanism to selectively switch one illumination angle to another in accordance with the focal length detected by the focal length detecting device, in response to the operation of the moving mechanism to move the flash unit from a non-projected position to a projected position.

Camera with pop-up flash having illumination angle variable with focal

A shutter for a camera includes a lever pivotable for operating a shutter, a shutter base plate formed from a synthetic resin, a shaft for pivotally supporting the lever, the shaft and the shutter base plate being formed from a synthetic resin as one unit, and a thick portion formed on the surface of the shutter base plate on which the shaft is formed. The thick portion is formed in a contiguous area of the shutter base plate surrounding the shaft so that the shaft surrounding area is made thicker than the area surrounding an aperture of the shutter base plate.

Shutter for camera

A camera includes a flash unit as a built-in unit. The camera includes a motor disposed in a camera body, a moving mechanism for causing the flash unit to move from a non-projected position to a projected position, an illumination-angle switching mechanism for varying an illumination angle of the flash unit, the illumination-angle switching mechanism being driven by means of a rotation of the motor in one direction and being capable of stopping in any one of a plurality of specific illumination angle states, and an engagement mechanism arranged to engage to hold the flash unit at the non-projected position, the engagement mechanism being arranged to engage when the illumination-angle switching mechanism is stopped in any one of the plurality of specific illumination angle states, and to be disengaged by means of the rotation of the motor in the aforesaid one direction.

Camera with valuable illumination angle pop-up flash

A camera with a built-in or removable, zoom flash unit having an illumination angle that varies automatically in accordance with the focal length of a photographic zoom lens that is attached to the camera. The camera inhibits the shutter release until the illumination angle of the zoom flash unit has reached a value corresponding with the focal length selected for the zoom lens.

Camera having a zoom flash unit

A camera having a red-eye phenomenon preventing emission device, the camera comprising, a shutter having a leading curtain and a trailing curtain, a flash unit capable of flashing in a range of time between immediately after a completion of a running of the leading curtain to immediately before a start of a running of the trailing curtain, and emission control means which disables the red-eye phenomenon preventing emission device when the flash unit is set for flashing immediately before the start of a running of the trailing curtain.

Growing community of inventors

Kanagawa, Japan

Tsuyoshi Fukuda