Nippon Chemiphar Co., Ltd.

Kinki University

J-Pharma Co., Ltd.

Dethree Res. Lab. Inc.

Tsuyoshi Endo

Toshihiro Takahashi

Daisuke Saito

Tomio Yamakawa

Hiroto Tanaka

Shogo Sakuma

Kunio Kobayashi

Takashi Kanda

Seiichiro Masui

Hitoshi Endou

Shinichi Yoshida

Atsushi Tendo

Atsufumi Kawabata

Masaaki Hirose

Isao Ooi

Masuharu Hirano

Toru Ogawa

Rie Takahashi

Kaoru Hara

Naohiko Anzai

Takaichi Hamano

Mai Okamura

Yuzo Mogi

Nobutaka Mochizuki

Toshihiro Kunigami

Hirano Masuharu

A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: 

Voltage-dependent t-type calcium channel blocker

Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formula (III), R, R, R, and Rrepresent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or a cyano group, Rand Rform a benzene ring or a 5-membered heteroaryl ring containing 1 to 3 heteroatoms, as a ring constituent element, selected from nitrogen atoms, oxygen atoms, and sulfur atoms together with two carbon atoms to which Rand Rare bonded, Rand Rform a benzene ring together with two carbon atoms to which Rand Rare bonded or represent any of the groups represented by Rdescribed above, Wrepresents CRor N, and where, Rrepresents any of the groups represented by R, Xrepresents an oxygen atom or a sulfur atom, Yrepresents an alkylene chain having 1 to 8 carbon atoms, and where, the alkylene chain may be substituted with an alkyl group having 1 to 8 carbon atoms and the alkylene chain may be a linear or branched alkylene chain, the branched alkylene chain may have a 3- to 7-membered ring formed by side chains bonded to carbon atoms which are the same as or different from each other, together with the carbon atoms to which the side chains are bonded and may have a double bond in the middle thereof, and Zrepresents COH). 

URAT1 inhibitor

A cyclic amine derivative represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes. 

GPR119 agonist

A phenylacetic acid derivative represented by the general formula (II) (wherein Rand Reach represents hydrogen, Calkyl, Calkoxy, Calkyl substituted by one to three halogen atoms, an optionally substituted phenyl, naphthyl, pyridyl, thienyl, or furyl group, etc.; Xand Zeach represents &#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;O)NH, &#x2014;NHC(&#x2550;O)&#x2014;, &#x2014;CH&#x2550;CH&#x2014;, a bond, etc.; and Yrepresents a Calkylene chain) or a salt of the derivative; and a PPAR&#x3b4; activator which contains the derivative or salt as the active ingredient 

Activator for peroxisome proliferator-activated receptor

Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R and R each are hydrogen, C alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X and X are each a free valency, oxygen, S(O) (wherein p is an integer of 0 to 2), C(&boxH;O), C(&boxH;O)NH, NHC(&boxH;O), CH&boxH;CH, or the like; Y is optionally substituted C alkylene; Z is oxygen or sulfur; R and R are each optionally substituted C alkyl; and R is hydrogen or C alkyl, with the proviso that when X is a free valency, X is not O or S(O) , while when X is C(&boxH;O)NH, X is not a free valency.

PPAR delta activators

Growing community of inventors

Misato, Japan

Tsuyoshi Endo